Cletoquine oxalate
Modify Date: 2024-01-09 19:49:58
Cletoquine oxalate structure
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Common Name | Cletoquine oxalate | ||
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| CAS Number | 14142-64-4 | Molecular Weight | 397.85300 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H24ClN3O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Cletoquine oxalateCletoquine oxalate (Desethylhydroxychloroquine oxalate) is a major active metabolite of Hydroxychloroquine. Cletoquine oxalate is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine oxalate is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine oxalate has antimalarial effects and has the potential for autoimmune diseases treatment[1][2]. |
| Name | 2-[4-[(7-chloroquinolin-4-yl)amino]pentylamino]ethanol,oxalic acid |
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| Synonym | More Synonyms |
| Description | Cletoquine oxalate (Desethylhydroxychloroquine oxalate) is a major active metabolite of Hydroxychloroquine. Cletoquine oxalate is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine oxalate is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine oxalate has antimalarial effects and has the potential for autoimmune diseases treatment[1][2]. |
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| Related Catalog | |
| Target |
Chikungunya virus (CHIKV)[2] |
| In Vivo | Hydroxychloroquine (5 mg/kg intravenously) is administered to BALB/c mice for blood and tissue to determine the content of Cletoquine (Desethylhydroxychloroquine). The tissue to blood concentration ratio (Kp) is ≥1, indicating accumulation of Cletoquine in tissues. The Cletoquine Kp ratio for the various tissues are observed in the descending order of liver (114.3)>kidney (24.4)>spleen (19.3)>lungs (16.5)>heart (5.5)[3]. |
| References |
| Molecular Formula | C18H24ClN3O5 |
|---|---|
| Molecular Weight | 397.85300 |
| Exact Mass | 397.14000 |
| PSA | 131.78000 |
| LogP | 2.67020 |
| Cletoquine Oxalate |