Cletoquine oxalate

Modify Date: 2025-08-26 20:17:07

Cletoquine oxalate structure	Common Name	Cletoquine oxalate
	CAS Number	14142-64-4	Molecular Weight	397.85300
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₂₄ClN₃O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Cletoquine oxalate

Cletoquine oxalate (Desethylhydroxychloroquine oxalate) is a major active metabolite of Hydroxychloroquine. Cletoquine oxalate is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine oxalate is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine oxalate has antimalarial effects and has the potential for autoimmune diseases treatment[1][2].

Name	2-[4-[(7-chloroquinolin-4-yl)amino]pentylamino]ethanol,oxalic acid
Synonym	More Synonyms

Description	Cletoquine oxalate (Desethylhydroxychloroquine oxalate) is a major active metabolite of Hydroxychloroquine. Cletoquine oxalate is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine oxalate is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine oxalate has antimalarial effects and has the potential for autoimmune diseases treatment[1][2].
Related Catalog	Signaling Pathways >> Anti-infection >> Influenza Virus Research Areas >> Infection Research Areas >> Inflammation/Immunology
Target	Chikungunya virus (CHIKV)[2]
In Vivo	Hydroxychloroquine (5 mg/kg intravenously) is administered to BALB/c mice for blood and tissue to determine the content of Cletoquine (Desethylhydroxychloroquine). The tissue to blood concentration ratio (Kp) is ≥1, indicating accumulation of Cletoquine in tissues. The Cletoquine Kp ratio for the various tissues are observed in the descending order of liver (114.3)>kidney (24.4)>spleen (19.3)>lungs (16.5)>heart (5.5)[3].
References	[1]. Kumar M, et al. Molecular docking studies of chloroquine and its derivatives against P23pro-zbd domain of chikungunya virus: Implication in designing of novel therapeutic strategies. J Cell Biochem. 2019 Oct;120(10):18298-18308. [2]. Charlier B, et al. Development of a novel ion-pairing HPLC-FL method for the separation and quantification of hydroxychloroquine and its metabolites in whole blood. Biomed Chromatogr. 2018 Aug;32(8):e4258. [3]. Chhonker YS, et al. Simultaneous quantitation of hydroxychloroquine and its metabolites in mouse blood and tissues using LC-ESI-MS/MS: An application for pharmacokinetic studies. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jan 1;1072:320-327.

Molecular Formula	C₁₈H₂₄ClN₃O₅
Molecular Weight	397.85300
Exact Mass	397.14000
PSA	131.78000
LogP	2.67020
InChIKey	DTVGVTDECKJJJK-UHFFFAOYSA-N
SMILES	CC(CCCNCCO)Nc1ccnc2cc(Cl)ccc12.O=C(O)C(=O)O

Cletoquine Oxalate

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Product Name: Cletoquine oxalate
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