QS-21
Modify Date: 2025-08-27 11:02:30
QS-21 structure
|
Common Name | QS-21 | ||
|---|---|---|---|---|
| CAS Number | 141256-04-4 | Molecular Weight | 1990.13 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C92H148O46 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of QS-21QS-21, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21 stimulates Th2 humoral and Th1 cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21 can activate the NLRP3 inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18[1][2][3]. |
| Name | 61H83WZX3U |
|---|---|
| Synonym | More Synonyms |
| Description | QS-21, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21 stimulates Th2 humoral and Th1 cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21 can activate the NLRP3 inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18[1][2][3]. |
|---|---|
| Related Catalog | |
| Target |
NLRP3 inflammasome |
| In Vivo | Studies in mouse APCs (DCs and macrophages) identifie QS-21 as an activator of the NLRP3 inflammasome, and cause subsequent release of caspase-1 dependent proinflammatory cytokines I1-1β/I1-18 that can promote Th 17 cell maturation or drive INF-γ-mediated Th1 responses, respectively[3]. |
| References |
| Molecular Formula | C92H148O46 |
|---|---|
| Molecular Weight | 1990.13 |
| InChIKey | DRHZYJAUECRAJM-DWSYSWFDSA-N |
| SMILES | CCC(C)C(CC(O)CC(=O)OC1C(C)OC(OC(=O)C23CCC(C)(C)CC2C2=CCC4C5(C)CCC(OC6OC(C(=O)O)C(O)C(OC7OCC(O)C(O)C7O)C6OC6OC(CO)C(O)C(O)C6O)C(C)(C=O)C5CCC4(C)C2(C)CC3O)C(OC2OC(C)C(OC3OCC(O)C(OC4OCC(O)(CO)C4O)C3O)C(O)C2O)C1O)OC(=O)CC(O)CC(OC1OC(CO)C(O)C1O)C(C)CC |
| Hazard Codes | Xi |
|---|
| 61H83WZX3U |