D-Cl-amidine

Modify Date: 2024-01-05 09:08:06

D-Cl-amidine structure	Common Name	D-Cl-amidine
	CAS Number	1404060-15-6	Molecular Weight	310.78
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₄H₁₉ClN₄O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of D-Cl-amidine

D-Cl-amidine is a potent and highly selective PAD1 inhibitor. D-Cl-amidine is well-torelated with no significant toxicity[1].

Name	D-Cl-amidine

Description	D-Cl-amidine is a potent and highly selective PAD1 inhibitor. D-Cl-amidine is well-torelated with no significant toxicity[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Protein Arginine Deiminase
In Vitro	D-Cl-amidine (200-400 μM) is effective in significantly decreasing cell viability in MDA-MB-231 cells[1]. D-Cl-amidine increase caspase 3 activity, indicating that inhibition of PAD1 leads to an increase in apoptosis[1].
In Vivo	D-Cl-amidine, administered by iv at a dose of 2.5 mg/kg, is still detected after 2 h in serum at a concentration of ~21 nM and at 4 h at ~10 nM. D-Cl-amidine is still observed in the blood serum at a concentration of ∼10 nM at 4 h when administered by ip at a dose of 10 mg/kg[1].
References	[1]. Bicker KL, et al. D-amino acid based protein arginine deiminase inhibitors: Synthesis, pharmacokinetics, and in cellulo efficacy. ACS Med Chem Lett. 2012 Oct 26;3(12):1081-1085.

Molecular Formula	C₁₄H₁₉ClN₄O₂
Molecular Weight	310.78