DC Chemicals Limited
China
Product Name: BB-Cl-Amidine
Price: $1100.0/100mg $2200.0/250mg $4400.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

1802637-39-3

1802637-39-3 structure

1802637-39-3 structure

Name: BB-Cl-Amidine
Chemical Name: BB-Cl-Amidine
CAS Number: 1802637-39-3
Molecular Formula: C₂₆H₂₆ClN₅O
Molecular Weight: 459.970
Catalog: Research Areas Inflammation/Immunology
Create Date: 2019-01-20 19:05:48
Modify Date: 2024-01-13 19:32:28
BB-Cl-Amidine is a peptidylarginine deminase (PAD) inhibitor.

Name	BB-Cl-Amidine
Synonyms	N-{(1S)-1-(1H-Benzimidazol-2-yl)-4-[(2-chloroethanimidoyl)amino]butyl}-4-biphenylcarboxamide [1,1'-Biphenyl]-4-carboxamide, N-[(1S)-1-(1H-benzimidazol-2-yl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-

Description	BB-Cl-Amidine is a peptidylarginine deminase (PAD) inhibitor.
Related Catalog	Signaling Pathways >> Epigenetics >> Protein Arginine Deiminase Research Areas >> Inflammation/Immunology
Target	PAD[1].
In Vitro	Cl-amidine and BB-Cl-amidine show similar in vitro potencies and selectivities; however, the cellular potency of BB-Cl-amidine is increased by more than 20-fold, evidenced by decreased EC50 values obtained from viability studies with U2OS osteosarcoma cells (8.8±0.6 μM vs >200 μM for Cl-amidine). Cl-amidine and BB-Cl-amidine significantly inhibit NET formation by MRL/lpr neutrophils[1].
In Vivo	Treatment with BB-Cl-amidine subtly reduces splenomegaly in MRL/lpr mice, while there is a trend towards increased circulating levels of anti-NET antibodies with PAD inhibitor treatment. However, neither PAD inhibitor affected body weight or total IgG levels. Indeed, treatment with both Cl-amidine and BB-Cl-amidine significantly improves endothelium-dependent vasorelaxation. The BB-Cl-amidine group also shows a strong trend towards downregulation of IRGs. Treatment with either Cl-amidine or BB-Cl-amidine significantly improves muzzle alopecia, in many cases preventing it entirely[1].
Animal Admin	Mice[1] MRL/lpr mice are treated with either Cl-amidine (Cl-am; 10 mg/kg/day) or BB-Cl-amidine (BB-Cl-am; 1 mg/kg/day) by daily subcutaneous injection from 8 to 14 weeks of age[1].
References	[1]. Knight JS, et al. Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lpr mice. Ann Rheum Dis. 2015 Dec;74(12):2199-206.

Density	1.3±0.1 g/cm3
Molecular Formula	C₂₆H₂₆ClN₅O
Molecular Weight	459.970
Exact Mass	459.182587
LogP	3.86
Index of Refraction	1.655
Storage condition	2-8℃