KT-195
Modify Date: 2024-01-06 09:08:16
KT-195 structure
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Common Name | KT-195 | ||
|---|---|---|---|---|
| CAS Number | 1402612-58-1 | Molecular Weight | 438.521 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 658.7±65.0 °C at 760 mmHg | |
| Molecular Formula | C27H26N4O2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 352.2±34.3 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
Use of KT-195KT-195 is a potent and selective inhibitor of serine hydrolase ABHD6 (α/β-hydrolase domain-containing protein 6) with IC50 of 10 nM; displays negligible activity against other serine hydrolases such as DAGLβ; induce a significant accumulation of 2-AG in Neuro2a cells; inhibits A23187-stimulated arachidonic acid release (IC50=0.7 uM) and LDH release from IMLF−/−; inhibits MPTP formation and cell death, blocks mitochondrial calcium uptak. |
| Name | [4-(4'-Methoxy-4-biphenylyl)-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)methanone |
|---|---|
| Synonym | More Synonyms |
| Description | KT-195 is a potent and selective inhibitor of serine hydrolase ABHD6 (α/β-hydrolase domain-containing protein 6) with IC50 of 10 nM; displays negligible activity against other serine hydrolases such as DAGLβ; induce a significant accumulation of 2-AG in Neuro2a cells; inhibits A23187-stimulated arachidonic acid release (IC50=0.7 uM) and LDH release from IMLF−/−; inhibits MPTP formation and cell death, blocks mitochondrial calcium uptak. |
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| References | References 1. Hsu KL, et al. Nat Chem Biol. 2012 Dec;8(12):999-1007. 2. Yun B, et al. J Biol Chem. 2014 Jan 17;289(3):1491-504. View Related Products by Target Other Targets |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 658.7±65.0 °C at 760 mmHg |
| Molecular Formula | C27H26N4O2 |
| Molecular Weight | 438.521 |
| Flash Point | 352.2±34.3 °C |
| Exact Mass | 438.205566 |
| LogP | 4.58 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.648 |
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301-H413 |
| Precautionary Statements | P301 + P310 + P330 |
| RIDADR | UN 2811 6.1 / PGIII |
| Methanone, [4-(4'-methoxy[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)- |
| [4-(4'-Methoxy-4-biphenylyl)-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)methanone |