Fmoc-Lys-OH hydrochloride

Modify Date: 2024-01-02 18:25:49

Fmoc-Lys-OH hydrochloride Structure
Fmoc-Lys-OH hydrochloride structure
 Common Name Fmoc-Lys-OH hydrochloride
CAS Number 139262-23-0 Molecular Weight 404.887
Density N/A Boiling Point 607.6ºC at 760 mmHg
Molecular Formula C21H25ClN2O4 Melting Point N/A
MSDS USA Flash Point 321.3ºC

 Use of Fmoc-Lys-OH hydrochloride


Fmoc-Lys-OH hydrochloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Lys-OH hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].

 Names

Name (2S)-6-amino-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid,hydrochloride
Synonym More Synonyms

 Fmoc-Lys-OH hydrochloride Biological Activity

Description Fmoc-Lys-OH hydrochloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Lys-OH hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].
Related Catalog
Target

Non-cleavable
In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

 Chemical & Physical Properties

Boiling Point 607.6ºC at 760 mmHg
Molecular Formula C21H25ClN2O4
Molecular Weight 404.887
Flash Point 321.3ºC
Exact Mass 404.150299
PSA 101.65000
LogP 5.00050
Vapour Pressure 1.29E-15mmHg at 25°C
Index of Refraction -11.0 ° (C=1, DMF)
Storage condition 2-8°C

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2924299090

 Customs

HS Code 2924299090
Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

Nalpha-Fmoc-L-lysinehydrochloride
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-aminohexanoic acid hydrochloride
Fmoc-Lys-OH hydrochloride
Nα-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-lysine Hydrochloride
Fmoc-Lys-OH.HCl
Fmoc-L-lysine HCl
N2-Fmoc-L-lysine HCl
MFCD00190889
Fmoc-L-lysine hydrochloride
Nalpha-Fmoc-L-Lysine Hydrochloride
L-Lysine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, hydrochloride (1:1)
Nalpha-[(9H-Fluoren-9-ylMethoxy)carbonyl]-L-lysine Hydrochloride
Fmoc-Lys-OH inverted exclamation mark currencyHCl
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-lysine hydrochloride (1:1)
Nα-Fmoc-L-lysine Hydrochloride
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Chemsrc provides Fmoc-Lys-OH hydrochloride(CAS#:139262-23-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Fmoc-Lys-OH hydrochloride are included as well.>> amp version: Fmoc-Lys-OH hydrochloride

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