Tenofovir Alafenamide Hemifumarate structure
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Common Name | Tenofovir Alafenamide Hemifumarate | ||
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CAS Number | 1392275-56-7 | Molecular Weight | 534.50 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C21H29N6O5P.1/2C4H4O4 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of Tenofovir Alafenamide HemifumarateTenofovir alafenamide hemifumarate (GS-7340 hemifumarate) is an investigational oral prodrug of Tenofovir. Tenofovir is a HIV-1 nucleotide reverse transcriptase inhibitor. |
Name | Tenofovir Alafenamide Hemifumarate |
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Synonym | More Synonyms |
Description | Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) is an investigational oral prodrug of Tenofovir. Tenofovir is a HIV-1 nucleotide reverse transcriptase inhibitor. |
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Related Catalog | |
Target |
HIV-1, NRTIs[1] |
In Vitro | Tenofovir alafenamide (GS-7340) antiviral activities are similar across all cell types, ranging from 5 to 7 nM, while the CC50 varies from 4.7 to 42 μM for MT-4 and MT-2 cells, respectively. The antiviral activity of TAF is evaluated against a panel of HIV-1 and HIV-2 isolates, including HIV-1 group M subtypes A to G, as well as group N and O isolates. Overall, for the 29 primary HIV-1 isolates tested in PBMCs, TAF EC50s range from 0.1 to 12 nM, with a mean EC50 of 3.5 nM compared to a mean EC50 of 11.8 nM for AZT, which is used as an internal control. For the HIV-2 isolates, the mean EC50s are 1.8 nM for TAF and 6.4 nM for AZT[2]. |
In Vivo | Tenofovir alafenamide (GS-7340) is an amidate prodrug of Tenofovir with good oral bioavailability and increases plasma stability compared to Tenofovir disoproxil fumarate (TDF) [1]. |
References |
Molecular Formula | C21H29N6O5P.1/2C4H4O4 |
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Molecular Weight | 534.50 |
PSA | 381.18000 |
LogP | 7.60180 |
Storage condition | 2-8°C |
Hazard Codes | Xi |
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GS-7340-03 |
Isopropyl N-[(S)-({[(2R)-1-(6-amino-9H-purin-9-yl)-2-propanyl]oxy}methyl)(phenoxy)phosphoryl]-L-alaninate (2E)-2-butenedioate (2:1) |
GS-7340 Hemifumarate |
1-Methylethyl N-((S)-(((1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy)methyl)phenoxyphosphinoyl)-L-alaninate,(2E)-2-butenedioate |
Tenofovir alafenamide fumarate, 2:1 |
L-Alanine, N-[(S)-[(1S)-[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-, 1-methylethyl ester, (2E)-2-butenedioate (2:1) |
L-Alanine,N-((S)-(((1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy)methyl)phenoxyphosphinyl)-,1-methylethyl ester,(2E)-2-butenedioate (2:1) |
Tenofovir alafenamide fumarate |
(E)-but-2-enedioic acid,propan-2-yl (2S)-2-[[1-(6-aminopurin-9-yl)propan-2-yloxymethyl-phenoxyphosphoryl]amino]propanoate |
enofovir Alafenamide Fumarate |
GS-7340 (hemifumarate) |