Cabazitaxel-d9

Modify Date: 2024-01-10 16:50:29

Cabazitaxel-d9 structure	Common Name	Cabazitaxel-d9
	CAS Number	1383572-19-7	Molecular Weight	844.99
	Density	1.3±0.1 g/cm3	Boiling Point	870.7±65.0 °C at 760 mmHg
	Molecular Formula	C₄₅H₄₈D₉NO₁₄	Melting Point	N/A
	MSDS	N/A	Flash Point	480.4±34.3 °C

Use of Cabazitaxel-d9

Cabazitaxel-d9 is deuterium labeled Cabazitaxel. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity.

Name	Cabazitaxel-d9
Synonym	More Synonyms

Description	Cabazitaxel-d9 is deuterium labeled Cabazitaxel. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Tai X, et al. Cabazitaxel and indocyanine green co-delivery tumor-targeting nanoparticle for improved antitumor efficacy and minimized drug toxicity. J Drug Target. 2016 Sep 9:1-29. [3]. Gdowski AS, et al. Bone-targeted cabazitaxel nanoparticles for metastatic prostate cancer skeletal lesions and pain. Nanomedicine (Lond). 2017 Sep;12(17):2083-2095.

Density	1.3±0.1 g/cm3
Boiling Point	870.7±65.0 °C at 760 mmHg
Molecular Formula	C₄₅H₄₈D₉NO₁₄
Molecular Weight	844.99
Flash Point	480.4±34.3 °C
Exact Mass	844.434387
LogP	7.55
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.592

Benzenepropanoic acid, β-[[[[1,1-di(methyl-d3)ethyl-2,2,2-d3]oxy]carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12 ; a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-

Cabazitaxel-d9

(2α,5β,7β,10β,13α)-4-Acetoxy-1-hydroxy-13-({(2R,3S)-2-hydroxy-3-[({[2-(2H3)methyl(2H6)-2-propanyl]oxy}carbonyl)amino]-3-phenylpropanoyl}oxy)-7,10-dimethoxy-9-oxo-5,20-epoxytax -11-en-2-yl benzoate

Cabazitaxel-d9

Use of Cabazitaxel-d9

Names

Cabazitaxel-d9 Biological Activity

Chemical & Physical Properties

Synonyms