mGlu5 PAM 4k
Modify Date: 2025-10-02 20:29:30
mGlu5 PAM 4k structure
|
Common Name | mGlu5 PAM 4k | ||
|---|---|---|---|---|
| CAS Number | 1382782-16-2 | Molecular Weight | 338.342 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H15FN4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of mGlu5 PAM 4kA potent, selective, CNS penetrant and orally bioavailable mGlu5 positive allosteric modulator that potentiates human mGlu5 with EC50 of 130 nM; displays 50-fold selectivity over mGlu3, and no activity against mGlu1/2/4/6/7/8; shows antipsychotic-like activity in vivo and for treatment of schizophrenia. |
| Name | mGlu5 PAM 4k |
|---|
| Description | A potent, selective, CNS penetrant and orally bioavailable mGlu5 positive allosteric modulator that potentiates human mGlu5 with EC50 of 130 nM; displays 50-fold selectivity over mGlu3, and no activity against mGlu1/2/4/6/7/8; shows antipsychotic-like activity in vivo and for treatment of schizophrenia. |
|---|---|
| References | References 1. Conde-Ceide S, et al. Bioorg Med Chem Lett. 2016 Jan 15;26(2):429-434. View Related Products by Target mGluR |
| Molecular Formula | C18H15FN4O2 |
|---|---|
| Molecular Weight | 338.342 |