mGlu5 PAM 4k

Names

[ Name ]:
mGlu5 PAM 4k

Biological Activity

[Description]:

A potent, selective, CNS penetrant and orally bioavailable mGlu5 positive allosteric modulator that potentiates human mGlu5 with EC50 of 130 nM; displays 50-fold selectivity over mGlu3, and no activity against mGlu1/2/4/6/7/8; shows antipsychotic-like activity in vivo and for treatment of schizophrenia.

[References]

References 1. Conde-Ceide S, et al. Bioorg Med Chem Lett. 2016 Jan 15;26(2):429-434. View Related Products by Target mGluR

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₁₅FN₄O₂

[ Molecular Weight ]:
338.342

Related Compounds

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