ARN1468
Modify Date: 2024-01-11 20:55:23
ARN1468 structure
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Common Name | ARN1468 | ||
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| CAS Number | 1381459-14-8 | Molecular Weight | 354.33 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H17F3N4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ARN1468ARN1468 (compound 5) is an orally active and potent serpins inhibitor. ARN1468 can inhibit serpins activity would set the protease free to further reduce prion accumulation. ARN1468 shows anti-prion effect in ScGT1 RML, ScGT1 22L, ScN2a RML, and ScN2a 22L cell lines, with EC50 values of 8.64, 19.3, 11.2, and 6.27 μM[1]. |
| Name | ARN1468 |
|---|
| Description | ARN1468 (compound 5) is an orally active and potent serpins inhibitor. ARN1468 can inhibit serpins activity would set the protease free to further reduce prion accumulation. ARN1468 shows anti-prion effect in ScGT1 RML, ScGT1 22L, ScN2a RML, and ScN2a 22L cell lines, with EC50 values of 8.64, 19.3, 11.2, and 6.27 μM[1]. |
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| Related Catalog | |
| In Vivo | ARN1468 (compound 5) (3 mg/kg, IV; 10 mg/kg, PO; once) reveals low brain concentrations and high plasma clearance in male C57BL/6 mice[1]. |
| References |
| Molecular Formula | C16H17F3N4O2 |
|---|---|
| Molecular Weight | 354.33 |