1381459-14-8

1381459-14-8 structure

Name: ARN1468
Chemical Name: ARN1468
CAS Number: 1381459-14-8
Molecular Formula: C₁₆H₁₇F₃N₄O₂
Molecular Weight: 354.33
Catalog: Research Areas Infection
Create Date: 2022-08-17 15:22:35
Modify Date: 2024-01-11 20:55:23
ARN1468 (compound 5) is an orally active and potent serpins inhibitor. ARN1468 can inhibit serpins activity would set the protease free to further reduce prion accumulation. ARN1468 shows anti-prion effect in ScGT1 RML, ScGT1 22L, ScN2a RML, and ScN2a 22L cell lines, with EC50 values of 8.64, 19.3, 11.2, and 6.27 μM[1].

Name	ARN1468

Description	ARN1468 (compound 5) is an orally active and potent serpins inhibitor. ARN1468 can inhibit serpins activity would set the protease free to further reduce prion accumulation. ARN1468 shows anti-prion effect in ScGT1 RML, ScGT1 22L, ScN2a RML, and ScN2a 22L cell lines, with EC50 values of 8.64, 19.3, 11.2, and 6.27 μM[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Others >> Others
In Vivo	ARN1468 (compound 5) (3 mg/kg, IV; 10 mg/kg, PO; once) reveals low brain concentrations and high plasma clearance in male C57BL/6 mice[1].
References	[1]. Colini Baldeschi A, et al. Innovative Non-PrP-Targeted Drug Strategy Designed to Enhance Prion Clearance. J Med Chem. 2022 Jun 30.

Molecular Formula	C₁₆H₁₇F₃N₄O₂
Molecular Weight	354.33