Ribocil
Modify Date: 2025-08-27 12:07:32
Ribocil structure
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Common Name | Ribocil | ||
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| CAS Number | 1381289-58-2 | Molecular Weight | 382.483 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 610.4±65.0 °C at 760 mmHg | |
| Molecular Formula | C19H22N6OS | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 323.0±34.3 °C | |
Use of RibocilRibocil is a highly selective chemical modulator of bacterial riboflavin riboswitches. Ribocil strongly inhibits GFP expression, achieving a 50% effective concentration (EC50) of 0.3 μM.Target: in vitro: Ribocil is a highly specific bioactive synthetic mimic of FMN, which competes with the natural ligand to inhibit FMN riboswitch-mediated expression of ribB and inhibits bacterial growth. Ribocil-B demonstrates superior microbiological activity as compared to Ribocil-A (minimum inhibitory concentration (MIC) = 1 μg/ml versus MIC ≥ 64 μg/ml), inhibition of riboflavin synthesis (IC50 = 0.13 μM versus IC50 > 26 μM), and binding affinity to the E. coli FMN aptamer (Kd = 6.6 nM versus Kd ≥ 10,000 nM).[1] |
| Name | Ribocil |
|---|---|
| Synonym | More Synonyms |
| Description | Ribocil is a highly selective chemical modulator of bacterial riboflavin riboswitches. Ribocil strongly inhibits GFP expression, achieving a 50% effective concentration (EC50) of 0.3 μM.Target: in vitro: Ribocil is a highly specific bioactive synthetic mimic of FMN, which competes with the natural ligand to inhibit FMN riboswitch-mediated expression of ribB and inhibits bacterial growth. Ribocil-B demonstrates superior microbiological activity as compared to Ribocil-A (minimum inhibitory concentration (MIC) = 1 μg/ml versus MIC ≥ 64 μg/ml), inhibition of riboflavin synthesis (IC50 = 0.13 μM versus IC50 > 26 μM), and binding affinity to the E. coli FMN aptamer (Kd = 6.6 nM versus Kd ≥ 10,000 nM).[1] |
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| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 610.4±65.0 °C at 760 mmHg |
| Molecular Formula | C19H22N6OS |
| Molecular Weight | 382.483 |
| Flash Point | 323.0±34.3 °C |
| Exact Mass | 382.157593 |
| LogP | 0.99 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.673 |
| Storage condition | 2-8℃ |
| 4-Pyrimidinol, 2-[1-[[2-(methylamino)-5-pyrimidinyl]methyl]-3-piperidinyl]-6-(2-thienyl)- |
| 2-(1-{[2-(Methylamino)-5-pyrimidinyl]methyl}-3-piperidinyl)-6-(2-thienyl)-4(1H)-pyrimidinone |