2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide

Modify Date: 2024-01-10 21:32:00

2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide structure	Common Name	2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide
	CAS Number	137089-36-2	Molecular Weight	339.57900
	Density	0.954g/cm3	Boiling Point	503.3ºC at 760 mmHg
	Molecular Formula	C₂₀H₃₇NOS	Melting Point	N/A
	MSDS	N/A	Flash Point	258.2ºC

Use of 2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide

2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide is a compound that inhibits stress-induced ulcer and low toxicity, and can maintain the content of phospholipase A2 and prostaglandin E2 in ulcerated rats induced by water immersed restrained stress.

Name	(E)-N-[2-(2-cyclohexylethylsulfanyl)ethyl]dec-2-enamide
Synonym	More Synonyms

Description	2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide is a compound that inhibits stress-induced ulcer and low toxicity, and can maintain the content of phospholipase A2 and prostaglandin E2 in ulcerated rats induced by water immersed restrained stress.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor Research Areas >> Others
Target	PGE2 PGI2 PLA2
In Vivo	2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide (compd.III-1α, 100 mg/kg, p.o.) maintains the relative content of Fr.I hexose, lipid peroxide and phospholipase A2 (PLA2) in normal level in ulcerated rats induced by water immersed restrained stress via dosing twice a day for 3 day (b.i.d. for 3 d). 2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide (100 mg/kg, p.o.) reduces the hexosamine content equally with the control group 4 h after the stress loading, and then markedly increases 7 h after stress loading. 2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide (25 mg/kg, p.o.) blocks the reduction of prostaglandin E2 (PGE2) and PGI2 in early phase and accelerates the increase of PGE2 and PGI2 in the late phase of the stress. 2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide (25 mg/kg, p.o.) also significantly accelerates the cell proliferation in fundic glands in gastric mucosa of mice[1].
References	[1]. Kohda I, et al. Further studies on the anti-ulcerogenic effects of compound, 2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide. Chem Pharm Bull (Tokyo). 1991 Jul;39(7):1832-6.

Density	0.954g/cm3
Boiling Point	503.3ºC at 760 mmHg
Molecular Formula	C₂₀H₃₇NOS
Molecular Weight	339.57900
Flash Point	258.2ºC
Exact Mass	339.26000
PSA	57.89000
LogP	6.56320
Vapour Pressure	2.93E-10mmHg at 25°C
Index of Refraction	1.498