SKA-111
Modify Date: 2024-01-05 11:28:52
SKA-111 structure
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Common Name | SKA-111 | ||
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| CAS Number | 1369170-24-0 | Molecular Weight | 214.286 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C12H10N2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SKA-111A potent, selective intermediate-conductance KCa3.1 positive-gating modulator with EC50 of 111 nM; displays 123-fold selectivity over KCa2.3 (EC50=13.7 uM), and 200- to 400-fold selective over representative KV, NaV, as well as CaV1.2 channels; not only lowers blood pressure but also drastically reduces heart rate, presumably through cardiac and neuronal KCa2 activation in mice. |
| Name | SKA-111 |
|---|
| Description | A potent, selective intermediate-conductance KCa3.1 positive-gating modulator with EC50 of 111 nM; displays 123-fold selectivity over KCa2.3 (EC50=13.7 uM), and 200- to 400-fold selective over representative KV, NaV, as well as CaV1.2 channels; not only lowers blood pressure but also drastically reduces heart rate, presumably through cardiac and neuronal KCa2 activation in mice. |
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| References | References 1. Coleman N, et al. Mol Pharmacol. 2014 Sep;86(3):342-57. 2. Oliván-Viguera A, et al. Basic Clin Pharmacol Toxicol. 2016 Aug;119(2):184-92. View Related Products by Target Potassium Channel |
| Molecular Formula | C12H10N2S |
|---|---|
| Molecular Weight | 214.286 |