1369170-24-0
1369170-24-0 structure
- Name: SKA-111
- Chemical Name: SKA-111
- CAS Number: 1369170-24-0
- Molecular Formula: C12H10N2S
- Molecular Weight: 214.286
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
- Create Date: 2020-01-20 17:39:57
- Modify Date: 2024-01-05 11:28:52
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A potent, selective intermediate-conductance KCa3.1 positive-gating modulator with EC50 of 111 nM; displays 123-fold selectivity over KCa2.3 (EC50=13.7 uM), and 200- to 400-fold selective over representative KV, NaV, as well as CaV1.2 channels; not only lowers blood pressure but also drastically reduces heart rate, presumably through cardiac and neuronal KCa2 activation in mice.
| Name | SKA-111 |
|---|
| Description | A potent, selective intermediate-conductance KCa3.1 positive-gating modulator with EC50 of 111 nM; displays 123-fold selectivity over KCa2.3 (EC50=13.7 uM), and 200- to 400-fold selective over representative KV, NaV, as well as CaV1.2 channels; not only lowers blood pressure but also drastically reduces heart rate, presumably through cardiac and neuronal KCa2 activation in mice. |
|---|---|
| References | References 1. Coleman N, et al. Mol Pharmacol. 2014 Sep;86(3):342-57. 2. Oliván-Viguera A, et al. Basic Clin Pharmacol Toxicol. 2016 Aug;119(2):184-92. View Related Products by Target Potassium Channel |
| Molecular Formula | C12H10N2S |
|---|---|
| Molecular Weight | 214.286 |