Vaborbactam
Modify Date: 2024-01-02 20:18:06
Vaborbactam structure
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Common Name | Vaborbactam | ||
|---|---|---|---|---|
| CAS Number | 1360457-46-0 | Molecular Weight | 297.135 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C12H16BNO5S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of VaborbactamVaborbactam is a cyclic boronic acid pharmacophore β-lactamase inhibitor. |
| Name | vaborbactam |
|---|---|
| Synonym | More Synonyms |
| Description | Vaborbactam is a cyclic boronic acid pharmacophore β-lactamase inhibitor. |
|---|---|
| Related Catalog | |
| In Vitro | Vaborbactam is a broad spectrum of inhibition of β-lactamases, with particularly potent activity against KPC, CTX-M, SHV, and CMY enzymes[1]. Vaborbactam restores meropenem activity for 72.7 to 98.1% of CPE isolates at ≤2 μg/mL, and maximum potentiation is achieved with fixed concentrations of ≥8 μg/mL of the inhibitor (≥96.5% of isolates are inhibited at ≤2 μg/mL of meropenem-vaborbactam). Meropenem-vaborbactam with a fixed concentration of 8 μg/mL of the inhibitor (MIC50, ≤0.06 μg/mL for all organisms) inhibits 93.7% of the CPE isolates displaying elevated meropenem MICs at ≤1 μg/mL[2]. By forming a reversible dative bond with the blactamase, vaborbactam acts as a competitive inhibitor and is not hydrolyzed by the b-lactamase[3]. |
| In Vivo | Vaborbactam is well tolerated and has a half-life of 1.23 h, and steadystate volume of distribution of 21.0 L in subjects[3]. |
| References |
[3]. Wong D, et al. Novel Beta-Lactamase Inhibitors: Unlocking Their Potential in Therapy. |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C12H16BNO5S |
| Molecular Weight | 297.135 |
| Exact Mass | 297.084229 |
| Index of Refraction | 1.572 |
| Storage condition | 2-8℃ |
| 1,2-Oxaborinane-6-acetic acid, 2-hydroxy-3-[[2-(2-thienyl)acetyl]amino]-, (3R,6S)- |
| {(3R,6S)-2-Hydroxy-3-[(2-thienylacetyl)amino]-1,2-oxaborinan-6-yl}acetic acid |
| RPX7009 |
| UNII:1C75676F8V |
| vaborbactam |