15-Keto latanoprost

Modify Date: 2024-01-12 13:39:46

15-Keto latanoprost Structure
15-Keto latanoprost structure
Common Name 15-Keto latanoprost
CAS Number 135646-98-9 Molecular Weight 430.58
Density 1.2±0.1 g/cm3 Boiling Point 594.2±50.0 °C at 760 mmHg
Molecular Formula C26H38O5 Melting Point N/A
MSDS N/A Flash Point 327.2±26.6 °C

 Use of 15-Keto latanoprost


15-Keto latanoprost is a metabolite of Latanoprost, which is an ocular hypotensive agent[1].

 Names

Name propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-(3-oxo-5-phenylpentyl)cyclopentyl]hept-5-enoate
Synonym More Synonyms

 15-Keto latanoprost Biological Activity

Description 15-Keto latanoprost is a metabolite of Latanoprost, which is an ocular hypotensive agent[1].
Related Catalog
In Vivo In cynomolgus monkeys, the acid of Latanoprost had a short half-life in plasma and it is partly converted to the 15-keto acid of latanoprost. β-Oxidation of the acid of latanoprost was the major metabolic pathway[1].
References

[1]. B Sjöquist, et al. Pharmacokinetics of latanoprost in the cynomolgus monkey. 2nd communication: repeated topical administration on the eye. Arzneimittelforschung. 1999 Mar;49(3):234-9.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 594.2±50.0 °C at 760 mmHg
Molecular Formula C26H38O5
Molecular Weight 430.58
Flash Point 327.2±26.6 °C
Exact Mass 386.209320
PSA 83.83000
LogP 1.90
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.608

 Synonyms

(5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-(3-oxo-5-phenylpentyl)cyclopentyl]-5-heptenoic Acid 1-Methylethyl Ester
Isopropyl (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-(3-oxo-5-phenylpentyl)cyclopentyl]-5-heptenoate
5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-(3-oxo-5-phenylpentyl)cyclopentyl]-, 1-methylethyl ester, (5Z)-
15-Ketolatanoprost
(5Z)-7-{(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E)-3-oxo-5-phenyl-1-penten-1-yl]cyclopentyl}-5-heptenoic acid
[1R-[1|A(Z),2|A,3|A,5|A]]-7-[3,5-Dihydroxy-2-(3-oxo-5-phenylpentyl)cyclopentyl]-5-heptenoic Acid 1-Methylethyl Ester
5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E)-3-oxo-5-phenyl-1-penten-1-yl]cyclopentyl]-, (5Z)-