26441-05-4

26441-05-4 structure

Name: 15-keto Prostaglandin E2
Chemical Name: 15-dehydro-prostaglandin E2
CAS Number: 26441-05-4
Molecular Formula: C₂₀H₃₀O₅
Molecular Weight: 350.45
Catalog: Signaling Pathways Cell Cycle/DNA Damage PPAR
Create Date: 2017-09-19 10:05:08
Modify Date: 2024-01-11 09:39:34
15-keto-Prostaglandin E2 is an endogenous metabolite. 15-keto-Prostaglandin E2 inhibits STAT3 activation by binding to its Cys259 residue. 15-keto-Prostaglandin E2 can bind and stabilize EP2 and EP4 receptor. 15-keto-Prostaglandin E2 inhibits breast cancer cell growth and progression. 15-keto-Prostaglandin E2 activates PPAR-γ and promotes fungal growth[1][2][3].

Name	15-dehydro-prostaglandin E2
Synonyms	Prosta-5,13-dien-1-oic acid, 11-hydroxy-9,15-dioxo-, (5Z,11α,13E)- 15-KetoPGE2 15-keto-prostaglandin E2 9,15-DIOXO-11ALPHA-HYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID 15-Oxoprostaglandin E2 (5Z,11α,13E)-11-Hydroxy-9,15-dioxoprosta-5,13-dien-1-oic acid 15-KETO PROSTAGLANDIN E2 15-keto Prostaglandin E2 Lipid Maps MS Standard

Description	15-keto-Prostaglandin E2 is an endogenous metabolite. 15-keto-Prostaglandin E2 inhibits STAT3 activation by binding to its Cys259 residue. 15-keto-Prostaglandin E2 can bind and stabilize EP2 and EP4 receptor. 15-keto-Prostaglandin E2 inhibits breast cancer cell growth and progression. 15-keto-Prostaglandin E2 activates PPAR-γ and promotes fungal growth[1][2][3].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> STAT Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> STAT Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR
References	[1]. Lee EJ, et al. 15-Keto prostaglandin E2 suppresses STAT3 signaling and inhibits breast cancer cell growth and progression. Redox Biol. 2019 May;23:101175. [2]. Kourpa A, et al. 15-keto-Prostaglandin E2 exhibits bioactive role by modulating glomerular cytoarchitecture through EP2/EP4 receptors. Life Sci. 2022 Dec 1;310:121114. [3]. Evans RJ, et al. 15-keto-prostaglandin E2 activates host peroxisome proliferator-activated receptor gamma (PPAR-γ) to promote Cryptococcus neoformans growth during infection. PLoS Pathog. 2019 Mar 28;15(3):e1007597.