Propargyl-PEG4-Boc

Modify Date: 2024-01-10 14:18:52

Propargyl-PEG4-Boc Structure
Propargyl-PEG4-Boc structure
Common Name Propargyl-PEG4-Boc
CAS Number 1355197-66-8 Molecular Weight 316.390
Density 1.0±0.1 g/cm3 Boiling Point 380.3±32.0 °C at 760 mmHg
Molecular Formula C16H28O6 Melting Point N/A
MSDS N/A Flash Point 162.2±25.2 °C

 Use of Propargyl-PEG4-Boc


Propargyl-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-Methyl-2-propanyl 4,7,10,13-tetraoxahexadec-15-yn-1-oate
Synonym More Synonyms

 Propargyl-PEG4-Boc Biological Activity

Description Propargyl-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 380.3±32.0 °C at 760 mmHg
Molecular Formula C16H28O6
Molecular Weight 316.390
Flash Point 162.2±25.2 °C
Exact Mass 316.188599
LogP 0.89
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.454

 Synonyms

MFCD22683285
4,7,10,13-Tetraoxahexadec-15-yn-1-oic acid, 1,1-dimethylethyl ester
2-Methyl-2-propanyl 4,7,10,13-tetraoxahexadec-15-yn-1-oate
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