Poseltinib
Modify Date: 2024-04-05 17:42:29
Poseltinib structure
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Common Name | Poseltinib | ||
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| CAS Number | 1353552-97-2 | Molecular Weight | 470.52 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H26N6O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PoseltinibPoseltinib, an orally active, selective and irreversible Bruton’s tyrosine kinase (BTK) inhibitor (IC50 =1.95 nM), with 0.3, 2.3 and 2.4-fold selectivity for BTK over BMX, TEC and TXK, respectively. Poseltinib can covalently bind to the active site (cysteine 481 residue) of BTK, and reveales potent inhibition of B cell receptor (BCR), Fc receptor (FcR), Toll-like receptor (TLR) mediated signaling[1]. |
| Name | Poseltinib |
|---|
| Description | Poseltinib, an orally active, selective and irreversible Bruton’s tyrosine kinase (BTK) inhibitor (IC50 =1.95 nM), with 0.3, 2.3 and 2.4-fold selectivity for BTK over BMX, TEC and TXK, respectively. Poseltinib can covalently bind to the active site (cysteine 481 residue) of BTK, and reveales potent inhibition of B cell receptor (BCR), Fc receptor (FcR), Toll-like receptor (TLR) mediated signaling[1]. |
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| Related Catalog | |
| Target |
IC50: 1.95 nM (BTK)[1] |
| References |
| Molecular Formula | C26H26N6O3 |
|---|---|
| Molecular Weight | 470.52 |
| InChIKey | LZMJNVRJMFMYQS-UHFFFAOYSA-N |
| SMILES | C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc(N4CCN(C)CC4)cc3)nc3ccoc23)c1 |