1353552-97-2

1353552-97-2 structure

Name: Poseltinib
Chemical Name: Poseltinib
CAS Number: 1353552-97-2
Molecular Formula: C₂₆H₂₆N₆O₃
Molecular Weight: 470.52
Catalog: Signaling Pathways Immunology/Inflammation Toll-like Receptor (TLR)
Create Date: 2019-10-06 18:27:13
Modify Date: 2024-04-05 17:42:29
Poseltinib, an orally active, selective and irreversible Bruton’s tyrosine kinase (BTK) inhibitor (IC50 =1.95 nM), with 0.3, 2.3 and 2.4-fold selectivity for BTK over BMX, TEC and TXK, respectively. Poseltinib can covalently bind to the active site (cysteine 481 residue) of BTK, and reveales potent inhibition of B cell receptor (BCR), Fc receptor (FcR), Toll-like receptor (TLR) mediated signaling[1].

Name	Poseltinib

Description	Poseltinib, an orally active, selective and irreversible Bruton’s tyrosine kinase (BTK) inhibitor (IC50 =1.95 nM), with 0.3, 2.3 and 2.4-fold selectivity for BTK over BMX, TEC and TXK, respectively. Poseltinib can covalently bind to the active site (cysteine 481 residue) of BTK, and reveales potent inhibition of B cell receptor (BCR), Fc receptor (FcR), Toll-like receptor (TLR) mediated signaling[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR) Signaling Pathways >> Protein Tyrosine Kinase/RTK >> BMX Kinase Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk Research Areas >> Metabolic Disease
Target	IC50: 1.95 nM (BTK)[1]
References	[1]. Kim YY, et al. HM71224, a selective Bruton's tyrosine kinase inhibitor, attenuates the development of murine lupus. Arthritis Res Ther. 2017 Sep 26;19(1):211.

Molecular Formula	C₂₆H₂₆N₆O₃
Molecular Weight	470.52