CMS121
Modify Date: 2025-08-22 18:44:52
CMS121 structure
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Common Name | CMS121 | ||
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| CAS Number | 1353224-53-9 | Molecular Weight | 321.37 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H19NO3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CMS121CMS-121 is a quinolone derivative and an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage with EC50 values of 7 nM and 200 nM, respectively. CMS-121 has strong neuroprotective, anti-inflammatory, antioxidative and renoprotective activities[1][2][3]. |
| Name | CMS-121 |
|---|
| Description | CMS-121 is a quinolone derivative and an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage with EC50 values of 7 nM and 200 nM, respectively. CMS-121 has strong neuroprotective, anti-inflammatory, antioxidative and renoprotective activities[1][2][3]. |
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| Related Catalog | |
| Target |
Acetyl-CoA carboxylase 1 (ACC1)[1] |
| In Vitro | CMS-121 (1 µM; 4 hours; HT22 cells) treatment increases the phosphorylation of ACC1 at serine 79. CMS-121 can increase acetyl-CoA in cells[1]. Western Blot Analysis[1] Cell Line: HT22 cells Concentration: 1 µM Incubation Time: 4 hours Result: Increases the phosphorylation of ACC1 at serine 79. |
| In Vivo | CMS-121 (~20 mg/kg; oral administration; daily; for 4 months; female SAMP8 mice) treatment reduces cognitive decline as well as metabolic and transcriptional markers of aging in the brain when administered to rapidly aging SAMP8 mice. CMS-121 preserves mitochondrial homeostasis by regulating acetyl-coenzyme A (acetyl-CoA) metabolism[1]. Animal Model: Female SAMP8 mice (9 months old)[1] Dosage: ~20 mg/kg/day Administration: Oral administration; daily; for 4 months Result: Reduced cognitive decline as well as metabolic and transcriptional markers of aging in the brain. |
| References |
| Molecular Formula | C20H19NO3 |
|---|---|
| Molecular Weight | 321.37 |
| InChIKey | OMHNVUCFPJJLKD-UHFFFAOYSA-N |
| SMILES | Oc1ccc(-c2cc(OC3CCCC3)c3ccccc3n2)cc1O |
| Storage condition | -20°C |