Theodrenaline

Modify Date: 2024-01-29 23:28:01

Theodrenaline Structure
Theodrenaline structure
Common Name Theodrenaline
CAS Number 13460-98-5 Molecular Weight 375.37900
Density 1.51g/cm3 Boiling Point 723.6ºC at 760mmHg
Molecular Formula C17H21N5O5 Melting Point N/A
MSDS N/A Flash Point 391.4ºC

 Use of Theodrenaline


Theodrenaline is a cardiac stimulant, also acts as an anti-hypotensive agent together with cafedrine.

 Names

Name 7-[2-[[2-(3,4-dihydroxyphenyl)-2-hydroxyethyl]amino]ethyl]-1,3-dimethylpurine-2,6-dione
Synonym More Synonyms

 Theodrenaline Biological Activity

Description Theodrenaline is a cardiac stimulant, also acts as an anti-hypotensive agent together with cafedrine.
Related Catalog
In Vitro Akrinor evokes a positive inotropic effect in human atrial trabeculae via stimulation of β-adrenoceptors (AR)[1].
In Vivo AkrinorTM produces significant potentiation of FSK effects, conceivable by PDE-inhibition, only at very high, clinically irrelevant concentrations of 420 mg/L[1].
References

[1]. Kloth B, et al. AkrinorTM, a Cafedrine/ Theodrenaline Mixture (20:1), Increases Force of Contraction of Human Atrial Myocardium But Does Not Constrict Internal Mammary Artery In Vitro. Front Pharmacol. 2017 May 23;8:272.

 Chemical & Physical Properties

Density 1.51g/cm3
Boiling Point 723.6ºC at 760mmHg
Molecular Formula C17H21N5O5
Molecular Weight 375.37900
Flash Point 391.4ºC
Exact Mass 375.15400
PSA 134.54000
Vapour Pressure 5.61E-22mmHg at 25°C
Index of Refraction 1.696
Storage condition 2-8℃

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XH5098600
CHEMICAL NAME :
Theophylline, 7-(2-((2-(3,4-dihydroxyphenyl)-2-hydroxyethyl)amino)e thyl)-
CAS REGISTRY NUMBER :
13460-98-5
BEILSTEIN REFERENCE NO. :
0590101
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C17-H21-N5-O5
MOLECULAR WEIGHT :
375.43
WISWESSER LINE NOTATION :
T56 BN DN FNVNVJ B2N2QR CQ DQ& F1 H1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1140 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,14,1977

 Synonyms

7-{2-[2-(3,4-dihydroxyphenyl)-2-hydroxyethylamino]-ethyl}-theophylline
Theodrenalina [DCIT]
7-(2-(2-Hydroxy-2-(3,4-dihydroxyphenyl)ethylamino)ethyl)theophylline
Noradrenaline theophylline
7-{2-[2-(3,4-dihydroxy-phenyl)-2-hydroxy-ethylamino]-ethyl}-1,3-dimethyl-3,7-dihydro-purine-2,6-dione
Theodrenalinum [INN-Latin]
theodrenaline
Norphedrinoethyltheophylline
D 470
Teodrenalina [INN-Spanish]
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