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Theodrenaline

Names

[ CAS No. ]:
13460-98-5

[ Name ]:
Theodrenaline

[Synonym ]:
7-{2-[2-(3,4-dihydroxyphenyl)-2-hydroxyethylamino]-ethyl}-theophylline
Theodrenalina [DCIT]
7-(2-(2-Hydroxy-2-(3,4-dihydroxyphenyl)ethylamino)ethyl)theophylline
Noradrenaline theophylline
7-{2-[2-(3,4-dihydroxy-phenyl)-2-hydroxy-ethylamino]-ethyl}-1,3-dimethyl-3,7-dihydro-purine-2,6-dione
Theodrenalinum [INN-Latin]
theodrenaline
Norphedrinoethyltheophylline
D 470
Teodrenalina [INN-Spanish]

Biological Activity

[Description]:

Theodrenaline is a cardiac stimulant, also acts as an anti-hypotensive agent together with cafedrine.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)
Research Areas >> Cardiovascular Disease

[In Vitro]

Akrinor evokes a positive inotropic effect in human atrial trabeculae via stimulation of β-adrenoceptors (AR)[1].

[In Vivo]

AkrinorTM produces significant potentiation of FSK effects, conceivable by PDE-inhibition, only at very high, clinically irrelevant concentrations of 420 mg/L[1].

[References]

[1]. Kloth B, et al. AkrinorTM, a Cafedrine/ Theodrenaline Mixture (20:1), Increases Force of Contraction of Human Atrial Myocardium But Does Not Constrict Internal Mammary Artery In Vitro. Front Pharmacol. 2017 May 23;8:272.


[Related Small Molecules]

3-Isobutyl-1-methylxanthine | rolipram | PF-04957325 | AN-2728 | GLPG1690 | BAY-60-7550 | Icariin | Ibudilast | PF-8380 | TAK-063 | Dipyridamole | Cilostazol | GSK256066 | Cialis | Pentoxifylline

Chemical & Physical Properties

[ Density]:
1.51g/cm3

[ Boiling Point ]:
723.6ºC at 760mmHg

[ Molecular Formula ]:
C17H21N5O5

[ Molecular Weight ]:
375.37900

[ Flash Point ]:
391.4ºC

[ Exact Mass ]:
375.15400

[ PSA ]:
134.54000

[ Vapour Pressure ]:
5.61E-22mmHg at 25°C

[ Index of Refraction ]:
1.696

[ Storage condition ]:
2-8℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XH5098600
CHEMICAL NAME :
Theophylline, 7-(2-((2-(3,4-dihydroxyphenyl)-2-hydroxyethyl)amino)e thyl)-
CAS REGISTRY NUMBER :
13460-98-5
BEILSTEIN REFERENCE NO. :
0590101
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C17-H21-N5-O5
MOLECULAR WEIGHT :
375.43
WISWESSER LINE NOTATION :
T56 BN DN FNVNVJ B2N2QR CQ DQ& F1 H1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1140 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,14,1977

Related Compounds

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