D-kynurenine

Modify Date: 2024-01-03 18:24:33

D-kynurenine structure	Common Name	D-kynurenine
	CAS Number	13441-51-5	Molecular Weight	208.214
	Density	1.3±0.1 g/cm3	Boiling Point	466.6±45.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₁₂N₂O₃	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	236.0±28.7 °C

Use of D-kynurenine

D-kynurenine, a metabolite of D-tryptophan, can serve as the bioprecursor of kynurenic acid (KYNA) and 3-hydroxykynurenine. D-Kynurenine is an agonist for G protein-coupled receptor, GPR109B. D-Kynurenine is a substrate in a fluorometric assay of D-amino acid oxidase. D-kynurenine promotes epithelial-to-mesenchymal transition via activating aryl hydrocarbon receptor (AHR)[1][2][3][4].

Name	D-kynurenine
Synonym	More Synonyms

Description	D-kynurenine, a metabolite of D-tryptophan, can serve as the bioprecursor of kynurenic acid (KYNA) and 3-hydroxykynurenine. D-Kynurenine is an agonist for G protein-coupled receptor, GPR109B. D-Kynurenine is a substrate in a fluorometric assay of D-amino acid oxidase. D-kynurenine promotes epithelial-to-mesenchymal transition via activating aryl hydrocarbon receptor (AHR)[1][2][3][4].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> Aryl Hydrocarbon Receptor
Target	Human Endogenous Metabolite
In Vitro	D-kynurenine (10, 40, 60, and 100 µM) positively regulates the metastasis of 95D cells, a lung cancer cell line, which is reduced upon siRNAAhr treatment. Significant enhancement VIM expression was detected in the presence of D-kynurenine (10 and 40 µM). 10 µM D-kynurenine markedly attenuates E-cadherin level. 10 µM D-kynurenine-mediated changes of VIM and E-cadherin are substantially attenuated on siRNAAhr treatment as well. The evidences-10/40 µM D-kynurenine-induced up-regulation of CYP1A1, 10 µM D-kynurenine-induced increase of nuclear transfer of Ahr, and 10/40/60/100 µM D-kynurenine-induced enhancement of DER-luciferase activity-indicated that D-kynurenine Is capable of activating Ahr in fact[4].
References	[1]. Wang XD, et al. A method for the determination of D-kynurenine in biological tissues. Anal Bioanal Chem. 2013 Dec;405(30):9747-54. [2]. Irukayama-Tomobe Y, et al. Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor, GPR109B. Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3930-4. [3]. Kozaki A, et al. Fluorimetric assay for D-amino acid oxidase activity in rat brain homogenate by using D-kynurenine as a substrate. Biosci Trends. 2012 Oct;6(5):241-7. [4]. Duan Z, et al. Promoting epithelial-to-mesenchymal transition by D-kynurenine via activating aryl hydrocarbon receptor. Mol Cell Biochem. 2018 Nov;448(1-2):165-173.

Density	1.3±0.1 g/cm3
Boiling Point	466.6±45.0 °C at 760 mmHg
Molecular Formula	C₁₀H₁₂N₂O₃
Molecular Weight	208.214
Flash Point	236.0±28.7 °C
Exact Mass	208.084793
PSA	106.41000
LogP	1.09
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.626

D-kynurenine MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2922509090

Kynurenine

CAS#:343-65-7

L-Kynurenine

CAS#:2922-83-0

D-kynurenine

CAS#:13441-51-5

Literature: WO2010/148191 A2, ; Page/Page column 45-49; 61 ;

D-tryptophan

CAS#:153-94-6

D-kynurenine

CAS#:13441-51-5

Literature: Biochemistry, , vol. 49, # 12 p. 2647 - 2656

Precursor 2
CAS#:343-65-7 Kynurenine CAS#:153-94-6 D-tryptophan
DownStream 0

HS Code	2922509090
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor, GPR109B.

Proc. Natl. Acad. Sci. U. S. A. 106 , 3930-3934, (2009)

GPR109B (HM74) is a putative G protein-coupled receptor (GPCR) whose cognate ligands have yet to be characterized. GPR109B shows a high degree of sequence similarity to GPR109A, another GPCR that was ...

Purification and biochemical characterization of some of the properties of recombinant human kynureninase.

Eur. J. Biochem. 269 , 2069-2074, (2002)

Recombinant human kynureninase (L-kynurenine hydrolase, EC 3.7.1.3) was purified to homogeneity (60-fold) from Spodoptera frugiperda (Sf9) cells infected with baculovirus containing the kynureninase g...

Changes in the plasma concentrations of D-kynurenine and kynurenic acid in rats after intraperitoneal administration of tryptophan enantiomers.

Chirality 22 , 901-916, (2010)

An aqueous solution of enantiomerically pure tryptophan (Trp), namely, D-Trp or L-Trp (100 mg/kg), was administered intraperitoneally to male Sprague-Dawley rats. The time-course profiles of the rat p...

D-kynurenine

|A-Anthraniloyl-D-alanine

(2R)-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid

MFCD00133224

Benzenebutanoic acid, α,2-diamino-γ-oxo-, (αR)-

β-Anthraniloyl-D-alanine

D-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid

(R)-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: D-kynurenine
Price: ￥578.0/25mg ￥1968.0/100mg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Liu jia

DC Chemicals Limited
China
Product Name: D-Kynurenine
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: D-Kynurenine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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