I-SAP

Modify Date: 2022-03-26 19:30:48

I-SAP structure	Common Name	I-SAP
	CAS Number	133538-58-6	Molecular Weight	531.447
	Density	1.5±0.1 g/cm3	Boiling Point	606.3±61.0 °C at 760 mmHg
	Molecular Formula	C₂₂H₃₀INO₄S	Melting Point	N/A
	MSDS	N/A	Flash Point	320.5±33.2 °C

Use of I-SAP

I-SAP is a radioiodinated TXA2/PGH2 receptor antagonist. The bind between I-SAP and the receptors, is inhibited by the histidine modifying reagent diethyl-pyrocarbonate (DEPC)[1][2].

Name	(E)-7-[3-[(4-iodophenyl)sulfonylamino]-6,6-dimethyl-4-bicyclo[3.1.1]heptanyl]hept-5-enoic acid
Synonym	More Synonyms

Description	I-SAP is a radioiodinated TXA2/PGH2 receptor antagonist. The bind between I-SAP and the receptors, is inhibited by the histidine modifying reagent diethyl-pyrocarbonate (DEPC)[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor
Target	TXA2 Receptor
References	[1]. Saussy DL Jr, et al. Binding of a novel radioiodinated thromboxane A2/prostaglandin H2 antagonist to guinea pig lung membranes. Eicosanoids. 1992;5(1):1-4. [2]. Schrör K, et al. Inhibition of ligand binding to thromboxane A2/prostaglandin H2 receptors by diethylpyrocarbonate. Protection by receptor ligands and reversal by hydroxylamine. Biochem Pharmacol. 1995 Mar 30;49(7):921-7.

Density	1.5±0.1 g/cm3
Boiling Point	606.3±61.0 °C at 760 mmHg
Molecular Formula	C₂₂H₃₀INO₄S
Molecular Weight	531.447
Flash Point	320.5±33.2 °C
Exact Mass	531.093994
PSA	91.85000
LogP	6.37
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.623

5-Heptenoic acid, 7-[(1S,2S,3S,5R)-3-[[(4-iodophenyl)sulfonyl]amino]-6,6-dimethylbicyclo[3.1.1]hept-2-yl]-, (5Z)-

Isap acid

I-SAP

(5Z)-7-[(1S,2S,3S,5R)-3-{[(4-Iodophenyl)sulfonyl]amino}-6,6-dimethylbicyclo[3.1.1]hept-2-yl]-5-heptenoic acid

I-SAP

Use of I-SAP

Names

I-SAP Biological Activity

Chemical & Physical Properties

Synonyms