Fe-TMPyP

Modify Date: 2024-01-14 11:44:42

Fe-TMPyP Structure
Fe-TMPyP structure
Common Name Fe-TMPyP
CAS Number 133314-07-5 Molecular Weight 715.027
Density 1.4±0.1 g/cm3 Boiling Point N/A
Molecular Formula C45H62N8 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Fe-TMPyP


FeTMPyP is an orally active peroxynitrite (ONOO?) scavenger. FeTMPyP reduces nitrative stress and increases autophagy. FeTMPyP reduces PARP over-activation and neuroinflammation in chronic constriction injury (CCI)-induced rats, and ameliorates functional, behavioral and biochemical deficits[1][2].

 Names

Name FeTMPyP pentachloride
Synonym More Synonyms

 Fe-TMPyP Biological Activity

Description FeTMPyP is an orally active peroxynitrite (ONOO?) scavenger. FeTMPyP reduces nitrative stress and increases autophagy. FeTMPyP reduces PARP over-activation and neuroinflammation in chronic constriction injury (CCI)-induced rats, and ameliorates functional, behavioral and biochemical deficits[1][2].
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References

[1]. Zhang S, et al. Nitrative Stress-Related Autophagic Insufficiency Participates in Hyperhomocysteinemia-Induced Renal Aging. Oxid Med Cell Longev. 2020 Jan 25;2020:4252047.  

[2]. Komirishetty P, et al. FeTMPyP a peroxynitrite decomposition catalyst ameliorated functional and behavioral deficits in chronic constriction injury induced neuropathic pain in rats. Free Radic Res. 2021 Oct;55(9-10):1005-1017.  

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Molecular Formula C45H62N8
Molecular Weight 715.027
Exact Mass 714.509766
PSA 29.30000
LogP 7.88
Index of Refraction 1.783

 Synonyms

3,4-Metheno-4H-3a,3c,9b,12b-tetraazacyclopent[h]-s-indaceno[1,8-ef]acenaphthylene, 1,2,3,7a,8,9-hexahydro-7,10,13,14-tetrakis(1-methyl-4-piperidinyl)-
7,10,13,14-Tetrakis(1-methyl-4-piperidinyl)-1,2,3,7a,8,9-hexahydro-3,4-(metheno)-3a,3c,9b,12b-tetraazacyclopenta[h]-s-indaceno[1,8-ef]acenaphthylene
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