Fe-TMPyP

Names

[ Name ]:
Fe-TMPyP

[Synonym ]:
3,4-Metheno-4H-3a,3c,9b,12b-tetraazacyclopent[h]-s-indaceno[1,8-ef]acenaphthylene, 1,2,3,7a,8,9-hexahydro-7,10,13,14-tetrakis(1-methyl-4-piperidinyl)-
7,10,13,14-Tetrakis(1-methyl-4-piperidinyl)-1,2,3,7a,8,9-hexahydro-3,4-(metheno)-3a,3c,9b,12b-tetraazacyclopenta[h]-s-indaceno[1,8-ef]acenaphthylene

Biological Activity

[Description]:

FeTMPyP is an orally active peroxynitrite (ONOO?) scavenger. FeTMPyP reduces nitrative stress and increases autophagy. FeTMPyP reduces PARP over-activation and neuroinflammation in chronic constriction injury (CCI)-induced rats, and ameliorates functional, behavioral and biochemical deficits[1][2].

[Related Catalog]:

Signaling Pathways >> Autophagy >> Autophagy

Research Areas >> Inflammation/Immunology

[References]

[1]. Zhang S, et al. Nitrative Stress-Related Autophagic Insufficiency Participates in Hyperhomocysteinemia-Induced Renal Aging. Oxid Med Cell Longev. 2020 Jan 25;2020:4252047.

[2]. Komirishetty P, et al. FeTMPyP a peroxynitrite decomposition catalyst ameliorated functional and behavioral deficits in chronic constriction injury induced neuropathic pain in rats. Free Radic Res. 2021 Oct;55(9-10):1005-1017.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C₄₅H₆₂N₈

[ Molecular Weight ]:
715.027

[ Exact Mass ]:
714.509766

[ PSA ]:
29.30000

[ LogP ]:
7.88

[ Index of Refraction ]:
1.783

Related Compounds

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