Valacyclovir-d4 hydrochloride

Modify Date: 2024-01-15 19:56:44

Valacyclovir-d4 hydrochloride structure	Common Name	Valacyclovir-d4 hydrochloride
	CAS Number	1331910-75-8	Molecular Weight	364.82
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₃H₁₇D₄ClN₆O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Valacyclovir-d4 hydrochloride

Valacyclovir-d4 hydrochloride is the deuterium labeled Valacyclovir hydrochloride. Valacyclovir hydrochloride (Valaciclovir hydrochloride) is an orally active antiviral drug for herpes simplex, herpes zoster, and herpes B. Valacyclovir hydrochloride inhibits HSV-1 W (50=2.9 μg/ml). Valacyclovir hydrochloride is a prodrug of Aciclovir (HY-17422)[1][2][3][4][5].

Name	Valacyclovir-d4 hydrochloride

Description	Valacyclovir-d4 hydrochloride is the deuterium labeled Valacyclovir hydrochloride. Valacyclovir hydrochloride (Valaciclovir hydrochloride) is an orally active antiviral drug for herpes simplex, herpes zoster, and herpes B. Valacyclovir hydrochloride inhibits HSV-1 W (50=2.9 μg/ml). Valacyclovir hydrochloride is a prodrug of Aciclovir (HY-17422)[1][2][3][4][5].
Related Catalog	Signaling Pathways >> Anti-infection >> HSV Research Areas >> Infection
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Valacyclovir. New indication: for genital herpes, simpler administration. Can Fam Physician. 1999 Jul;45:1698-700, 1703-5. [3]. Lycke J, et al. Acyclovir levels in serum and cerebrospinal fluid after oral administration of valacyclovir. Antimicrob Agents Chemother. 2003 Aug;47(8):2438-41. [4]. Comparison of efficacies of famciclovir and valaciclovir against herpes simplex virus type 1 in a murineimmunosuppression model. Antimicrob Agents Chemother. 1995 May;39(5):1114-9. [5]. Dhaliwal DK, Romanowski EG, Yates KA, Valacyclovir inhibits recovery of ocular HSV-1 after experimental reactivation by excimer laser keratectomy. Cornea. 1999 Nov;18(6):693-9. [6]. Guo A, Hu P, Balimane PV, Interactions of a nonpeptidic drug, valacyclovir, with the human intestinal peptide transporter (hPEPT1) expressed in a mammalian cell line.J Pharmacol Exp Ther. 1999 Apr;289(1):448-54.

Molecular Formula	C₁₃H₁₇D₄ClN₆O₄
Molecular Weight	364.82

Valacyclovir-d4 hydrochloride

Use of Valacyclovir-d4 hydrochloride

Names

Valacyclovir-d4 hydrochloride Biological Activity

Chemical & Physical Properties