Eprosartan

Modify Date: 2024-01-08 11:24:55

Eprosartan structure	Common Name	Eprosartan
	CAS Number	133040-01-4	Molecular Weight	424.513
	Density	1.3±0.1 g/cm3	Boiling Point	660.6±55.0 °C at 760 mmHg
	Molecular Formula	C₂₃H₂₄N₂O₄S	Melting Point	250-253ºC
	MSDS	N/A	Flash Point	353.3±31.5 °C

Use of Eprosartan

Eprosartan (SKF-108566J free base) is a selective, competitive, nonpeptid and orally active angiotensin II receptor antagonist, used as an antihypertensive. Eprosartan binds angiotensin II receptor with IC50s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively [1].

Name	eprosartan
Synonym	More Synonyms

Description	Eprosartan (SKF-108566J free base) is a selective, competitive, nonpeptid and orally active angiotensin II receptor antagonist, used as an antihypertensive. Eprosartan binds angiotensin II receptor with IC50s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively [1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Angiotensin Receptor
In Vitro	Eprosartan (SKF-108566J) inhibits [125I]AII binding to human liver membranes (IC50 of 1.7 nM) and to rat mesenteric artery membranes (IC50 of 1.5 nM). In rabbit aortic smooth muscle cells, Eprosartan caused a concentration-dependent inhibition of AII-induced increases in intracellular Ca2+ levels[1].
In Vivo	In conscious normotensive rats, i.v. administration of Eprosartan (0.01-0.3 mg/kg) produced dose-dependent parallel shifts in the AII pressor dose-response curve. Administration of Eprosartan (3-10 mg/kg) intraduodenally or intragastrically to conscious normotensive rats resulted in a dose-dependent inhibition of the pressor response to AII (250 ng/kg, i.v.). At 10 mg/kg, i.d., significant inhibition of the pressor response to AII was observed for 3 hr[1].
References	[1]. R M Edwards, et al. Pharmacological characterization of the nonpeptide angiotensin II receptor antagonist, SK&F 108566. J Pharmacol Exp Ther. 1992 Jan;260(1):175-81.

Density	1.3±0.1 g/cm3
Boiling Point	660.6±55.0 °C at 760 mmHg
Melting Point	250-253ºC
Molecular Formula	C₂₃H₂₄N₂O₄S
Molecular Weight	424.513
Flash Point	353.3±31.5 °C
Exact Mass	424.145691
PSA	120.66000
LogP	4.96
Vapour Pressure	0.0±2.1 mmHg at 25°C
Index of Refraction	1.628
Storage condition	-20°C Freezer

Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S26

Precursor 9
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CAS#:133040-04-7 2-butyl-1-(4-ca...
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