fenamisal

Modify Date: 2024-01-02 12:35:38

fenamisal Structure
fenamisal structure
Common Name fenamisal
CAS Number 133-11-9 Molecular Weight 229.231
Density 1.3±0.1 g/cm3 Boiling Point 406.4±30.0 °C at 760 mmHg
Molecular Formula C13H11NO3 Melting Point 150-152 °C(lit.)
MSDS N/A Flash Point 199.6±24.6 °C

 Names

Name Phenyl-4-aminosalicylate
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 406.4±30.0 °C at 760 mmHg
Melting Point 150-152 °C(lit.)
Molecular Formula C13H11NO3
Molecular Weight 229.231
Flash Point 199.6±24.6 °C
Exact Mass 229.073898
PSA 72.55000
LogP 2.95
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.659

 MSDS

Name: Phenyl 4-Aminosalicylate 99% Material Safety Data Sheet
Synonym: Phenyl PAS; 4-Amino-2-Hydroxybenzoic Acid Phenyl Ester
CAS: 133-11-9
Section 1 - Chemical Product MSDS Name:Phenyl 4-Aminosalicylate 99% Material Safety Data Sheet
Synonym:Phenyl PAS; 4-Amino-2-Hydroxybenzoic Acid Phenyl Ester

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
133-11-9 Phenyl 4-Aminosalicylate 99% 205-092-8
Hazard Symbols: XI
Risk Phrases: 36/37/38

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Irritating to eyes, respiratory system and skin.
Potential Health Effects
Eye:
Causes eye irritation. May cause chemical conjunctivitis.
Skin:
Causes skin irritation.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea.
Inhalation:
Causes respiratory tract irritation. Can produce delayed pulmonary edema.
Chronic:
Effects may be delayed.

Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:
Treat symptomatically and supportively.

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Runoff from fire control or dilution water may cause pollution.
Extinguishing Media:
Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed.
Avoid ingestion and inhalation. Use with adequate ventilation.
Storage:
Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 133-11-9: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to minimize contact with skin.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Powder
Color: white
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 150.00 - 152.00 deg C
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: 0.7mg/100ml
Specific Gravity/Density:
Molecular Formula: C13H11NO3
Molecular Weight: 229.23

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
Incompatible materials, dust generation, excess heat, strong oxidants.
Incompatibilities with Other Materials:
Acid anhydrides, acid chlorides, acids, chloroformates, oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 133-11-9 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
Phenyl 4-Aminosalicylate - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION


Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI
Risk Phrases:
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 133-11-9: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 133-11-9 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 133-11-9 is not listed on the TSCA inventory.
It is for research and development use only.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36
WGK Germany 3
HS Code 2922509090

 Synthetic Route

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fenamisal Structure

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CAS#:133-11-9

Literature: Magyar kem. LapjaChem.Abstr., , vol. 4, p. 596,601 Magyar kem. LapjaChem.Abstr., , p. 116

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fenamisal Structure

fenamisal

CAS#:133-11-9

Literature: Zhurnal Obshchei Khimii, , vol. 22, p. 2014,2016; engl. Ausg. S. 2069, 2070

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fenamisal Structure

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CAS#:133-11-9

Literature: Magyar kem. LapjaChem.Abstr., , vol. 4, p. 596,601 Magyar kem. LapjaChem.Abstr., , p. 116

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fenamisal Structure

fenamisal

CAS#:133-11-9

Literature: Journal of the American Chemical Society, , vol. 74, p. 2589,2591

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fenamisal Structure

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CAS#:133-11-9

Literature: Journal of the American Chemical Society, , vol. 74, p. 2589,2591

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CAS#:133-11-9

Literature: US2829154 , ;

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CAS#:133-11-9

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CAS#:133-11-9

Literature: Magyar kem. LapjaChem.Abstr., , vol. 4, p. 596,601 Magyar kem. LapjaChem.Abstr., , p. 116

 Customs

HS Code 2922509090
Summary 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

Phenyl-PAS-Tebamin
phenyl 4-aminosalicylate
Tebanyl
Phenyl-4-aminosalicy
EINECS 205-092-8
fenamisal
Phenyl aminosalicylate
Pheny-Pas-Tebamin
4-Amino-2-hydroxy-benzoesaeure-phenylester
Phenyl p-Aminosalicylic Acid
phenyl-p-aminosalicylate
MFCD00007788
p-Aminosalol
Tebamin
Phenyl PAS
4-amino-2-hydroxy-benzoic acid phenyl ester
Salicylic acid, 4-amino-, phenyl ester (8CI)
4-amino-2-hydroxybenzoic acid phenyl ester
Benzoic acid, 4-amino-2-hydroxy-, phenyl ester
UNII-52936SIP7V
p-Aminosalicylic Acid Phenyl Ester
Phenyl 4-amino-2-hydroxybenzoate
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