Folpet

Modify Date: 2024-01-02 18:54:29

Folpet structure	Common Name	Folpet
	CAS Number	133-07-3	Molecular Weight	296.56
	Density	1.7±0.1 g/cm3	Boiling Point	333.8±52.0 °C at 760 mmHg
	Molecular Formula	C₉H₄Cl₃NO₂S	Melting Point	177-180°C
	MSDS	Chinese USA	Flash Point	155.7±30.7 °C
	Symbol	GHS07, GHS08, GHS09	Signal Word	Warning

Use of Folpet

Faltan is a dicarboximide fungicide, widely used on vines and several vegetable crops, and is also cytotoxic effect on human bronchial epithelial cells[1].

Name	folpet
Synonym	More Synonyms

Description	Faltan is a dicarboximide fungicide, widely used on vines and several vegetable crops, and is also cytotoxic effect on human bronchial epithelial cells[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal
References	[1]. Canal-Raffin M, et al. Cytotoxicity of folpet fungicide on human bronchial epithelial cells. Toxicology. 2008 Jul 30;249(2-3):160-6.

Density	1.7±0.1 g/cm3
Boiling Point	333.8±52.0 °C at 760 mmHg
Melting Point	177-180°C
Molecular Formula	C₉H₄Cl₃NO₂S
Molecular Weight	296.56
Flash Point	155.7±30.7 °C
Exact Mass	294.902832
PSA	62.68000
LogP	2.85
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.693
Water Solubility	practically insoluble

Folpet MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TI5685000

CHEMICAL NAME :: Phthalimide, N-((trichloromethyl)thio)-

CAS REGISTRY NUMBER :: 133-07-3

BEILSTEIN REFERENCE NO. :: 0193373

LAST UPDATED :: 199701

DATA ITEMS CITED :: 52

MOLECULAR FORMULA :: C9-H4-Cl3-N-O2-S

MOLECULAR WEIGHT :: 296.55

WISWESSER LINE NOTATION :: T56 BVNVJ CSXGGG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7540 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/m3/2H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 68400 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1546 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >6 gm/m3/2H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1115 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >22600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 437 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1000 mg/kg

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 500 mg/kg

SEX/DURATION :: male 5 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 500 mg/kg

SEX/DURATION :: male 5 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 491 mg/m3/4H

SEX/DURATION :: female 6-13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 900 mg/kg

SEX/DURATION :: female 6-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 900 mg/kg

SEX/DURATION :: female 6-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - urogenital system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 488 mg/kg

SEX/DURATION :: female 6-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 500 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 900 mg/kg

SEX/DURATION :: female 7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 600 mg/kg

SEX/DURATION :: female 7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TYPE OF TEST :: Dominant lethal test

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 250 ug/L

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 3,233,1981 *** REVIEWS *** TOXICOLOGY REVIEW MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 32,3,1975 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0327 No. of Facilities: 608 (estimated) No. of Industries: 4 No. of Occupations: 8 No. of Employees: 1240 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0327 No. of Facilities: 628 (estimated) No. of Industries: 8 No. of Occupations: 21 No. of Employees: 10509 (estimated) No. of Female Employees: 1422 (estimated)

Symbol	GHS07, GHS08, GHS09
Signal Word	Warning
Hazard Statements	H317-H319-H332-H351-H400
Precautionary Statements	P261-P273-P280-P304 + P340 + P312-P333 + P313-P337 + P313
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	Xn,N
Risk Phrases	R20
Safety Phrases	S36/37-S46-S61
RIDADR	UN 3077 9/PG 3
RTECS	TI5685000
HS Code	2930909057

Perchloromethyl...

CAS#:594-42-3

Folpet

CAS#:133-07-3

Literature: Science (Washington, DC, United States), , vol. 115, p. 84 US2553770 , ; US2553771 , ;

Potassium phtha...

CAS#:1074-82-4

Perchloromethyl...

CAS#:594-42-3

Folpet

CAS#:133-07-3

Literature: Naturwissenschaften, , vol. 44, p. 517 US2553776 , ;

phthalimide

CAS#:136918-14-4

Perchloromethyl...

CAS#:594-42-3

Folpet

CAS#:133-07-3

Literature: Acta Crystallographica Section C: Crystal Structure Communications, , vol. 56, # 1 p. 97 - 98

Precursor 2
CAS#:594-42-3 Perchloromethyl... CAS#:1074-82-4 Potassium phtha...
DownStream 0

HS Code	2930909057
Summary	2930909057 2-((trichloromethyl)thio)-3a,4,7,7a-tetrahydro-1h-isoindole-1,3(2h)-dione。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:30.0%

Toxicokinetics of captan and folpet biomarkers in orally exposed volunteers.

J. Appl. Toxicol. 32(3) , 194-201, (2012)

The time courses of key biomarkers of exposure to captan and folpet was assessed in accessible biological matrices of orally exposed volunteers. Ten volunteers ingested 1 mg kg(-1) body weight of cap...

Air pollutants formed in thermal decomposition of folpet fungicide under oxidative conditions.

Environ. Sci. Technol. 45(2) , 554-60, (2011)

This contribution studies the decomposition of folpet fungicide under oxidative conditions and compares the product species with those of captan fungicide, which is structurally related to folpet. Tox...

Liquid chromatography-tandem mass spectrometry (LC/APCI-MS/MS) methods for the quantification of captan and folpet phthalimide metabolites in human plasma and urine.

Anal. Bioanal. Chem 399(6) , 2243-55, (2011)

Captan and folpet are fungicides largely used in agriculture. They have similar chemical structures, except that folpet has an aromatic ring unlike captan. Their half-lives in blood are very short, gi...

Ftalan

N-trichloromethylsulfanyl-phthalimide

N-(trichloromethylthio)phthalimide

Faltan

Phthalimide, N-[(trichloromethyl)thio]-

EINECS 205-088-6

1H-Isoindole-1,3(2H)-dione, 2-[(trichloromethyl)thio]-

2-[(trichloromethyl)thio]-1H-isoindole-1,3(2H)-dione

2-(Trichloromethylsulfanyl)isoindole-1,3-dione

Spolacid

n-(trichloromethylmercapto)phthalimide

Folnit

Folpel

Folpan

PHALTAN

Orthophaltan

2-[(Trichloromethyl)sulfanyl]-1H-isoindole-1,3(2H)-dione

Phthaltan

N-(trichloromethanesulfenyl)phthalimide

2-((Trichloromethyl)thio)isoindoline-1,3-dione

MFCD00047303

Folpet

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Folpet
Price: ￥128.0/1ml
Purity: 98.0%
Stocking Period: Inquiry
Contact: Liu jia

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Folpet suppliers

Price: ￥880/10 mM * 1 mL in DMSO

Reference only. check more Folpet price

Folpet

Use of Folpet

Names

Folpet Biological Activity

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

Synthetic Route

Precursor & DownStream

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