Lansoprazole Sulfone

Modify Date: 2024-01-10 17:23:57

Lansoprazole Sulfone Structure
Lansoprazole Sulfone structure
Common Name Lansoprazole Sulfone
CAS Number 131926-99-3 Molecular Weight 385.361
Density 1.5±0.1 g/cm3 Boiling Point 555.6±60.0 °C at 760 mmHg
Molecular Formula C16H14F3N3O3S Melting Point 207ºC(dec.)
MSDS N/A Flash Point 289.8±32.9 °C

 Use of Lansoprazole Sulfone


Lansoprazole sulfone (AG-1813) is an orally active and selective inhibitor of H+, K+-ATPase. Lansoprazole sulfone can significantly stimulates gastric acid secretion by inhibiting H+, K+-ATPase. Lansoprazole sulfone has potential applications in duodenal ulcer, gastric ulcer, gastroesophageal reflux disease and Zolinger Ellison disease[1][2].

 Names

Name Lansoprazole Sulfone
Synonym More Synonyms

 Lansoprazole Sulfone Biological Activity

Description Lansoprazole sulfone (AG-1813) is an orally active and selective inhibitor of H+, K+-ATPase. Lansoprazole sulfone can significantly stimulates gastric acid secretion by inhibiting H+, K+-ATPase. Lansoprazole sulfone has potential applications in duodenal ulcer, gastric ulcer, gastroesophageal reflux disease and Zolinger Ellison disease[1][2].
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References

[1]. Swamy G, et al. Crystal structure of lansoprazole sulfone[J]. Journal of Structural Chemistry, 2007, 48: 715-718.

[2]. Karol MD, et al. Lansoprazole pharmacokinetics in subjects with various degrees of kidney function. Clin Pharmacol Ther. 1997 Apr;61(4):450-8.  

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 555.6±60.0 °C at 760 mmHg
Melting Point 207ºC(dec.)
Molecular Formula C16H14F3N3O3S
Molecular Weight 385.361
Flash Point 289.8±32.9 °C
Exact Mass 385.070801
PSA 93.32000
LogP 4.46
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.581

 Safety Information

RIDADR NONH for all modes of transport

 Synonyms

Lansoprazole Related Compound A
2-[[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfonyl]-1H-benzimidazole
1H-Benzimidazole, 2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfonyl]-
2-({[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl}sulfonyl)-1H-benzimidazole
2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfonyl]-1H-benzimidazole
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