Fudosteine

Modify Date: 2024-01-05 11:25:03

Fudosteine structure	Common Name	Fudosteine
	CAS Number	13189-98-5	Molecular Weight	179.237
	Density	1.3±0.1 g/cm3	Boiling Point	354.5±42.0 °C at 760 mmHg
	Molecular Formula	C₆H₁₃NO₃S	Melting Point	210.9-212.5ºC
	MSDS	N/A	Flash Point	168.2±27.9 °C

Use of Fudosteine

Fudosteine is a novel mucoactive agent and a MUC5AC mucin hypersecretion inhibitor.Target: OthersFudosteine is a cysteine derivative that is used as an expectorant in chronic bronchial inflammatory disorders. The administration of fudosteine during the challenge with ovalbumin prevented the development of airway hyperresponsiveness and accumulation of lymphocytes in the airways. Eotaxin, IL-4, and TGF-β levels and the relative intensity of matrix metalloproteinase-2 and matrix metalloproteinase-9 (MMP-2 and MMP-9) in BAL fluid were reduced by the fudosteine treatment; however, the number of eosinophils in BAL fluid and serum IgE levels did not change. The expression of TGF-β, the development of goblet cell hyperplasia, subepithelial collagenization, and basement membrane thickening were also reduced by the fudosteine treatment [1]. Fudosteine inhibits MUC5AC mucin hypersecretion by reducing MUC5AC gene expression and the effects of fudosteine are associated with the inhibition of extracellular signal-related kinase and p38 mitogen-activated protein kinase in vivo and extracellular signal-related kinase in vitro [2].

Name	Fudosteine
Synonym	More Synonyms

Description	Fudosteine is a novel mucoactive agent and a MUC5AC mucin hypersecretion inhibitor.Target: OthersFudosteine is a cysteine derivative that is used as an expectorant in chronic bronchial inflammatory disorders. The administration of fudosteine during the challenge with ovalbumin prevented the development of airway hyperresponsiveness and accumulation of lymphocytes in the airways. Eotaxin, IL-4, and TGF-β levels and the relative intensity of matrix metalloproteinase-2 and matrix metalloproteinase-9 (MMP-2 and MMP-9) in BAL fluid were reduced by the fudosteine treatment; however, the number of eosinophils in BAL fluid and serum IgE levels did not change. The expression of TGF-β, the development of goblet cell hyperplasia, subepithelial collagenization, and basement membrane thickening were also reduced by the fudosteine treatment [1]. Fudosteine inhibits MUC5AC mucin hypersecretion by reducing MUC5AC gene expression and the effects of fudosteine are associated with the inhibition of extracellular signal-related kinase and p38 mitogen-activated protein kinase in vivo and extracellular signal-related kinase in vitro [2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
References	[1]. Ueno-Iio, T., et al., Effect of fudosteine, a cysteine derivative, on airway hyperresponsiveness, inflammation, and remodeling in a murine model of asthma. Life Sci, 2013. 92(20-21): p. 1015-23. [2]. Rhee, C.K., et al., Effect of fudosteine on mucin production. Eur Respir J, 2008. 32(5): p. 1195-202.

Description

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

References

[1]. Ueno-Iio, T., et al., Effect of fudosteine, a cysteine derivative, on airway hyperresponsiveness, inflammation, and remodeling in a murine model of asthma. Life Sci, 2013. 92(20-21): p. 1015-23.

[2]. Rhee, C.K., et al., Effect of fudosteine on mucin production. Eur Respir J, 2008. 32(5): p. 1195-202.

Density	1.3±0.1 g/cm3
Boiling Point	354.5±42.0 °C at 760 mmHg
Melting Point	210.9-212.5ºC
Molecular Formula	C₆H₁₃NO₃S
Molecular Weight	179.237
Flash Point	168.2±27.9 °C
Exact Mass	179.061615
PSA	108.85000
LogP	-0.10
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.558
Storage condition	-20°C Freezer

Material Safety Data Sheet

Section1. Identiﬁcation of the substance
Product Name: Fudosteine
Synonyms:

Section2. Hazards identiﬁcation
Harmful by inhalation, in contact with skin, and if swallowed.

Section3. Composition/information on ingredients.
Ingredient name:Fudosteine
CAS number:13189-98-5

Section4. First aid measures
Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
ﬂushing of the eyes by separating the eyelids with ﬁngers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

Section5. Fire ﬁghting measures
In the event of a ﬁre involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

Section7. Handling and storage
Handling:This product should be handled only by, or under the close supervision of, those properly qualiﬁed
in the handling and use of potentially hazardous chemicals, who should take into account the ﬁre,
health and chemical hazard data given on this sheet.
Store in closed vessels, refrigerated.
Storage:

Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section9. Physical and chemical properties
Appearance:Not speciﬁed
Boiling point:No data
No data
Melting point:
Flash point:No data
Density:No data
Molecular formula:C6H13NO3S
Molecular weight:179.2

Section10. Stability and reactivity
Conditions to avoid: Heat, ﬂames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, sulfur oxides.

Section11. Toxicological information
No data.

Section12. Ecological information
No data.

Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

Section14. Transportation information
Non-harzardous for air and ground transportation.

Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

SECTION 16 - ADDITIONAL INFORMATION
N/A

Hazard Codes	Xi

FUDESTEINE

fudosteine

S-(3-Hydroxypropyl)-L-cysteine

L-Cysteine, S-(3-hydroxypropyl)-

MFCD00899873

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Fudosteine
Price: ￥228.0/50mg ￥758.0/250mg
Purity: 99.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Fudosteine
Price: $250.0/100mg $500.0/250mg $1000.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Zhejiang Hangyu API Co., Ltd
China
Product Name: Fudosteine
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

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Price: ￥210.6/50mg

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Fudosteine

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