FT-1518

Modify Date: 2024-04-02 21:38:19

FT-1518 structure	Common Name	FT-1518
	CAS Number	1313026-58-2	Molecular Weight	394.47
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₂₆N₈O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of FT-1518

FT-1518 is a new generation selective, potent and oral bioavailable mTORC1 and mTORC2 inhibitor, and exhibits antitumor activity.

Name	FT-1518

Description	FT-1518 is a new generation selective, potent and oral bioavailable mTORC1 and mTORC2 inhibitor, and exhibits antitumor activity.
Related Catalog	Research Areas >> Cancer
Target	mTORC1 mTORC2
In Vitro	FT-1518 is a new generation selective, potent and oral bioavailable mTORC1 and mTORC2 inhibitor, and exhibits antitumor activity. FT-1518 displays significant growth inhibitory activity against a large panel of hematologic and solid tumor cell lines with most activities falling into low nanomolar range. FT-1518 cuases potent inhibition of the mTOR pathway biomarkers (mTORC 1 & 2 biomarkers [pAkt(S473) and pS6(S240/244) or p70 S6K), no inhibition of PI3K biomarker [pAkt(T308)] in cells[1].
In Vivo	FT-1518 exhibits dose-dependent and higher tumor growth inhibition (TGI) in multiple solid tumor xenografts[1].
References	[1]. Alain C. Mita, et al. Abstract 137: FT-1518, a new generation selective and potent mTORC1 and mTORC2 inhibitor: an in vitro and in vivo profile. Cancer Res 2017;77(13 Suppl).

Molecular Formula	C₂₀H₂₆N₈O
Molecular Weight	394.47