AA26-9
Modify Date: 2024-01-03 14:18:39
AA26-9 structure
|
Common Name | AA26-9 | ||
|---|---|---|---|---|
| CAS Number | 1312782-34-5 | Molecular Weight | 166.180 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 306.7±25.0 °C at 760 mmHg | |
| Molecular Formula | C7H10N4O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 139.3±23.2 °C | |
Use of AA26-9AA26-9 is a potent and broad spectrum serine hydrolase inhibitor. |
| Name | AA26-9 |
|---|---|
| Synonym | More Synonyms |
| Description | AA26-9 is a potent and broad spectrum serine hydrolase inhibitor. |
|---|---|
| Related Catalog | |
| In Vitro | AA26-9 is synthesized based on a piperazine scaffold shown previously to inhibit serine hydrolases in the context of p-nitrophenoxy carbamate. AA26-9-inhibited enzymes originated from diverse functional subclasses of serine hydrolases, including lipases/phospholipases (AADACL1, ABHD6, ESD, FAAH, PAFAH2, LYPLA3), peptidases (APEH, PRCP, CTSA), thioesterases (LYPLA1, LYPLA2), and uncharacterized enzymes (ABHD11, ABHD13, BAT5). AA26-9 inhibits one of its enzyme targets LYPLA1 by covalent carbamoylation of the enzyme’s serine nucleophile (S114). AA26-9 inhibits 1/3 of the over 40 serine hydrolase found in T-cells[1]. |
| Cell Assay | Cells are cultured with 20 μM inhibitor AA26-9 or DMSO as a control for 4 h, lysed, separated into soluble and analyzed by competitive gel-based ABPP[1]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 306.7±25.0 °C at 760 mmHg |
| Molecular Formula | C7H10N4O |
| Molecular Weight | 166.180 |
| Flash Point | 139.3±23.2 °C |
| Exact Mass | 166.085464 |
| LogP | -0.78 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Index of Refraction | 1.691 |
| Storage condition | 2-8℃ |
| Pyrrolidin-1-yl(1H-1,2,3-triazol-1-yl)methanone |
| MFCD28386498 |
| Methanone, 1-pyrrolidinyl-1H-1,2,3-triazol-1-yl- |
| 1-Pyrrolidinyl(1H-1,2,3-triazol-1-yl)methanone |