TAK-659

Modify Date: 2024-01-10 19:55:58

TAK-659 structure	Common Name	TAK-659
	CAS Number	1312691-33-0	Molecular Weight	344.387
	Density	1.6±0.1 g/cm3	Boiling Point	661.7±55.0 °C at 760 mmHg
	Molecular Formula	C₁₇H₂₁FN₆O	Melting Point	N/A
	MSDS	N/A	Flash Point	354.0±31.5 °C

Use of TAK-659

TAK-659 is a highly potent, selective, reversible and orally available inhibitor of spleen tyrosine kinase (SYK) and fms related tyrosine kinase 3 (FLT3), with an IC50 of 3.2 nM for SYK. TAK-659 induces cell death in tumor cells but not in nontumor cells, and with potential for the treatment of chronic lymphocytic leukemia (CLL)[1][2][3][4].

Name	8QR88H79VX
Synonym	More Synonyms

Description	TAK-659 is a highly potent, selective, reversible and orally available inhibitor of spleen tyrosine kinase (SYK) and fms related tyrosine kinase 3 (FLT3), with an IC50 of 3.2 nM for SYK. TAK-659 induces cell death in tumor cells but not in nontumor cells, and with potential for the treatment of chronic lymphocytic leukemia (CLL)[1][2][3][4].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Syk Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FLT3
Target	IC50: 3.2 nM (Syk)[1]
References	[1]. Lam B, et al. Discovery of TAK-659 an orally available investigational inhibitor of Spleen Tyrosine Kinase (SYK). Bioorg Med Chem Lett. 2016 Dec 15;26(24):5947-5950. [2]. Purroy N, et al. Inhibition of BCR signaling using the Syk inhibitor TAK-659 prevents stroma-mediated signaling in chronic lymphocytic leukemia cells. Oncotarget. 2017 Jan 3;8(1):742-756. [3]. Jie Yu, et al. Anti-tumor activity of TAK-659, a dual inhibitor of SYK and FLT-3 kinases, in AML models. Journal of Clinical Oncology 34, no. 15_suppl. [4]. Cen O, et al. Spleen Tyrosine Kinase Inhibitor TAK-659 Prevents Splenomegaly and Tumor Development in a Murine Model of Epstein-Barr Virus-Associated Lymphoma. mSphere. 2018 Aug 22;3(4).

Density	1.6±0.1 g/cm3
Boiling Point	661.7±55.0 °C at 760 mmHg
Molecular Formula	C₁₇H₂₁FN₆O
Molecular Weight	344.387
Flash Point	354.0±31.5 °C
Exact Mass	344.176086
LogP	0.28
Vapour Pressure	0.0±2.0 mmHg at 25°C
Index of Refraction	1.756
Storage condition	2-8°C

6-{[(1R,2S)-2-Aminocyclohexyl]amino}-7-fluoro-4-(1-methyl-1H-pyrazol-4-yl)-1,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one

MFCD30829411

8QR88H79VX

3H-Pyrrolo[3,4-c]pyridin-3-one, 6-[[(1R,2S)-2-aminocyclohexyl]amino]-7-fluoro-1,2-dihydro-4-(1-methyl-1H-pyrazol-4-yl)-

DC Chemicals Limited
China
Product Name: TAK-659 free base
Price: $500.0/100mg $900.0/250mg $1800.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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TAK-659

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