NDMC101
Modify Date: 2025-08-25 12:19:59
NDMC101 structure
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Common Name | NDMC101 | ||
|---|---|---|---|---|
| CAS Number | 1308631-40-4 | Molecular Weight | 265.668 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 311.1±42.0 °C at 760 mmHg | |
| Molecular Formula | C13H9ClFNO2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 142.0±27.9 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of NDMC101NDMC101 is a potent osteoclastogenesis inhibitor and inhibits osteoclast differentiation via down-regulation of NFATc1-modulated gene express. NDMC101 is similar to the DPP4 substrate and is a significant inhibitor of early T-cell activation via DPP4 inhibition. NDMC101can be used for study of bone disorders, such as rheumatoid arthritis, and synovial inflammation et al[1]. |
| Name | N-(4-Chloro-2-fluorophenyl)-2-hydroxybenzamide |
|---|---|
| Synonym | More Synonyms |
| Description | NDMC101 is a potent osteoclastogenesis inhibitor and inhibits osteoclast differentiation via down-regulation of NFATc1-modulated gene express. NDMC101 is similar to the DPP4 substrate and is a significant inhibitor of early T-cell activation via DPP4 inhibition. NDMC101can be used for study of bone disorders, such as rheumatoid arthritis, and synovial inflammation et al[1]. |
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| Related Catalog | |
| In Vitro | NDMC101 (10-15 µM) inhibits RANKL-induced osteoclast differentiation of bone marrow-derived macrophages (BMDMs) and RAW 264.7 cells[1]. NDMC101 (15 µM) decreases RANKL-induced expression of the osteoclastogenic genes Nfatc1, Acp5, Ctsk, Oscar, Itgb3, and Dcstamp in BMDMs[1]. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 311.1±42.0 °C at 760 mmHg |
| Molecular Formula | C13H9ClFNO2 |
| Molecular Weight | 265.668 |
| Flash Point | 142.0±27.9 °C |
| Exact Mass | 265.030579 |
| LogP | 3.58 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Index of Refraction | 1.661 |
| InChIKey | NUQWCDAXACRITO-UHFFFAOYSA-N |
| SMILES | O=C(Nc1ccc(Cl)cc1F)c1ccccc1O |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| RIDADR | NONH for all modes of transport |
| Benzamide, N-(4-chloro-2-fluorophenyl)-2-hydroxy- |
| MFCD13200880 |
| N-(4-Chloro-2-fluorophenyl)-2-hydroxybenzamide |