Bindarit structure
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Common Name | Bindarit | ||
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CAS Number | 130641-38-2 | Molecular Weight | 324.374 | |
Density | 1.2±0.1 g/cm3 | Boiling Point | 542.9±40.0 °C at 760 mmHg | |
Molecular Formula | C19H20N2O3 | Melting Point | N/A | |
MSDS | N/A | Flash Point | 282.1±27.3 °C |
Use of BindaritBindarit(AF-2838), a CCL2, CCL7 and CCL8 inhibitor, is an anti-inflammatory agent.Target: OthersBindarit exhibits selective inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8. Oral administration of Bindarit at 50 mg/kg in NZB/W mice delays the onset of proteinuria, significantly protects from renal function impairment, and prolongs survival of NZB/W mice or lupus mice. Bindarit treatment completely MCP-1 up-regulation during the progression of nephritis [1]. Inhibition of MCP-1 with Bindarit also reduces tumor growth and macrophage recruitment, rendering necrotic tumor masses in human melanoma xenografts [2]. Bindarit is effective in reducing neointima formation in both non-hyperlipidaemic and hyperlipidaemic animal models of vascular injury by a direct effect on VSMC proliferation and migration and by reducing neointimal macrophage content [3]. Administration of Bindarit results in impaired metastatic disease in prostate cancer PC-3M-Luc2 xenograft mice and impairment of local tumorigenesis in Balb/c mice with murine breast cancer 4T1-Luc cells. In addition, Bindarit treatment significantly decreases the infiltration of tumor-associated macrophages and myeloid-derived suppressor cells in 4T1-Luc primary tumors [4]. |
Name | 2-[(1-benzylindazol-3-yl)methoxy]-2-methylpropanoic acid |
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Synonym | More Synonyms |
Description | Bindarit(AF-2838), a CCL2, CCL7 and CCL8 inhibitor, is an anti-inflammatory agent.Target: OthersBindarit exhibits selective inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8. Oral administration of Bindarit at 50 mg/kg in NZB/W mice delays the onset of proteinuria, significantly protects from renal function impairment, and prolongs survival of NZB/W mice or lupus mice. Bindarit treatment completely MCP-1 up-regulation during the progression of nephritis [1]. Inhibition of MCP-1 with Bindarit also reduces tumor growth and macrophage recruitment, rendering necrotic tumor masses in human melanoma xenografts [2]. Bindarit is effective in reducing neointima formation in both non-hyperlipidaemic and hyperlipidaemic animal models of vascular injury by a direct effect on VSMC proliferation and migration and by reducing neointimal macrophage content [3]. Administration of Bindarit results in impaired metastatic disease in prostate cancer PC-3M-Luc2 xenograft mice and impairment of local tumorigenesis in Balb/c mice with murine breast cancer 4T1-Luc cells. In addition, Bindarit treatment significantly decreases the infiltration of tumor-associated macrophages and myeloid-derived suppressor cells in 4T1-Luc primary tumors [4]. |
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Related Catalog | |
References |
Density | 1.2±0.1 g/cm3 |
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Boiling Point | 542.9±40.0 °C at 760 mmHg |
Molecular Formula | C19H20N2O3 |
Molecular Weight | 324.374 |
Flash Point | 282.1±27.3 °C |
Exact Mass | 324.147400 |
PSA | 64.35000 |
LogP | 3.44 |
Vapour Pressure | 0.0±1.5 mmHg at 25°C |
Index of Refraction | 1.595 |
Hazard Codes | Xi |
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HS Code | 2933990090 |
~% Bindarit CAS#:130641-38-2 |
Literature: WO2011/15501 A1, ; |
~% Bindarit CAS#:130641-38-2 |
Literature: WO2011/15501 A1, ; |
~% Bindarit CAS#:130641-38-2 |
Literature: WO2011/15501 A1, ; |
~% Bindarit CAS#:130641-38-2 |
Literature: WO2011/15501 A1, ; |
~% Bindarit CAS#:130641-38-2 |
Literature: WO2011/15501 A1, ; |
~% Bindarit CAS#:130641-38-2 |
Literature: WO2011/15501 A1, ; |
HS Code | 2933990090 |
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Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
2-[(1-Benzyl-1H-indazol-3-yl)methoxy]-2-methylpropanoic acid |
Bindarit (USAN/INN) |
2-((1-benzyl-1H-indazol-3-yl)methoxy)-2-methylpropanoic acid |
Propanoic acid, 2-methyl-2-[[1-(phenylmethyl)-1H-indazol-3-yl]methoxy]- |
bindarit |