Levocetirizine

Modify Date: 2024-01-04 06:47:26

Levocetirizine Structure
Levocetirizine structure
 Common Name Levocetirizine
CAS Number 130018-77-8 Molecular Weight 388.888
Density 1.2±0.1 g/cm3 Boiling Point 542.1±45.0 °C at 760 mmHg
Molecular Formula C21H25ClN2O3 Melting Point 205-208°C (dec.)
MSDS N/A Flash Point 281.6±28.7 °C

 Use of Levocetirizine


Levocetirizine ((R)-Cetirizine) is a third-generation peripheral H1-receptor antagonist. Levocetirizine is an antihistaminic agent which is the R-enantiomer of Cetirizine. Levocetirizine has a higher affinity for the histamine H1-receptor than (S)-Cetirizine and can effectively treat allergic rhinitis and chronic idiopathic urticaria[1].

 Names

Name Levocetirizine
Synonym More Synonyms

 Levocetirizine Biological Activity

Description Levocetirizine ((R)-Cetirizine) is a third-generation peripheral H1-receptor antagonist. Levocetirizine is an antihistaminic agent which is the R-enantiomer of Cetirizine. Levocetirizine has a higher affinity for the histamine H1-receptor than (S)-Cetirizine and can effectively treat allergic rhinitis and chronic idiopathic urticaria[1].
Related Catalog
Target

H1 receptor
In Vivo Levocetirizine (0.4 mg/kg; oral administration; male Sprague-Dawley rats) treatment shows that the Cmax, AUC0-t , AUC0-∞ and t1/2 are 0.34 μg/mL, 3.26 μg h/mL, 3.67 μg h/mL and 2.34 hours, respectively in Sprague-Dawley rats[1]. Animal Model: 30 male Sprague-Dawley rats (8 weeks old; 200-250 g)[1] Dosage: 0.4 mg/kg Administration: Oral administration (Pharmacokinetic Analysis) Result: The Cmax, AUC0-t , AUC0-∞ and t1/2 were 0.34 μg/mL, 3.26 μg h/mL, 3.67 μg h/mL and 2.34 hours, respectively.
References

[1]. Lohar P, et al. Simultaneous bioanalysis and pharmacokinetic interaction study of acebrophylline, levocetirizine and pranlukast in Sprague-Dawley rats. Biomed Chromatogr. 2019 Dec;33(12):e4672.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 542.1±45.0 °C at 760 mmHg
Melting Point 205-208°C (dec.)
Molecular Formula C21H25ClN2O3
Molecular Weight 388.888
Flash Point 281.6±28.7 °C
Exact Mass 388.155365
PSA 53.01000
LogP 2.16
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.589
Storage condition -20°C Freezer

 Safety Information

Hazard Codes Xn
HS Code 2933599090

 Synthetic Route

 Customs

HS Code 2933599090
Summary 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

Levocetirizine [INN]
vardenafilH
Acetic acid, (2-(4-((R)-(4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-
Vivanza
MFCD04112703
levocarnitine
(2-(4-((R)-(4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetic Acid
(2-{4-[(R)-(4-Chlorophenyl)(phenyl)methyl]-1-piperazinyl}ethoxy)acetic acid
(2-{4-[(R)-(4-Chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid
Vardenafil
(-)-Cetirizine
levocetirizinum
Acetic acid, 2-[2-[4-[(R)-(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-
(R)-Cetirizine
Levocetirizine
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Related Compounds: More...
Levocetirizine 2HCl
130018-87-0
Levocetirizine Impurity 4
70558-10-0
Levocetirizine hydrochloride
823178-28-5
levocetirizine N-benzyl amide
1150310-68-1
(S)-Cetirizine DiHCl (Levocetirizine S-Isomer DiHCl)
163837-48-7
Chemsrc provides Levocetirizine(CAS#:130018-77-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Levocetirizine are included as well.>> amp version: Levocetirizine

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