GSK2578215A

Modify Date: 2024-01-03 18:10:30

GSK2578215A structure	Common Name	GSK2578215A
	CAS Number	1285515-21-0	Molecular Weight	399.417
	Density	1.3±0.1 g/cm3	Boiling Point	556.1±50.0 °C at 760 mmHg
	Molecular Formula	C₂₄H₁₈FN₃O₂	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	290.1±30.1 °C

Use of GSK2578215A

GSK2578215A is a potent and highly selective LRRK2 inhibitor; exhibits IC50s of around 10 nM against both wild-type LRRK2 and the G2019S mutant.IC50 value: ~10 nM(wt-LRRK2; LRRK2 G2019S) [1]Target: LRRK2 inhibitorGSK2578215A exhibits exceptionally high selectivity for LRRK2 across the kinome, substantially inhibits Ser910 and Ser935 phosphorylation of both wild-type LRRK2 and G2019S mutant at a concentration of 0.3–1.0 μM in cells and in mouse spleen and kidney, but not in brain, following intraperitoneal injection of 100 mg/kg [1].

Name	5-(2-fluoropyridin-4-yl)-2-phenylmethoxy-N-pyridin-3-ylbenzamide
Synonym	More Synonyms

Description	GSK2578215A is a potent and highly selective LRRK2 inhibitor; exhibits IC50s of around 10 nM against both wild-type LRRK2 and the G2019S mutant.IC50 value: ~10 nM(wt-LRRK2; LRRK2 G2019S) [1]Target: LRRK2 inhibitorGSK2578215A exhibits exceptionally high selectivity for LRRK2 across the kinome, substantially inhibits Ser910 and Ser935 phosphorylation of both wild-type LRRK2 and G2019S mutant at a concentration of 0.3–1.0 μM in cells and in mouse spleen and kidney, but not in brain, following intraperitoneal injection of 100 mg/kg [1].
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Autophagy >> LRRK2 Signaling Pathways >> Autophagy >> Mitophagy Research Areas >> Neurological Disease
References	[1]. Reith AD, et al. GSK2578215A; a potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5625-9.

Density	1.3±0.1 g/cm3
Boiling Point	556.1±50.0 °C at 760 mmHg
Molecular Formula	C₂₄H₁₈FN₃O₂
Molecular Weight	399.417
Flash Point	290.1±30.1 °C
Exact Mass	399.138306
PSA	67.60000
LogP	3.40
Appearance of Characters	white to beige
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.651
Storage condition	2-8°C
Water Solubility	DMSO: soluble15mg/mL, clear

GSK2578215A MSDS(Chinese)

RIDADR	NONH for all modes of transport

Benzamide, 5-(2-fluoro-4-pyridinyl)-2-(phenylmethoxy)-N-3-pyridinyl-

SMANT hydrochloride

UNII-Q641JSF42X

GSK2578215A

2-(Benzyloxy)-5-(2-fluoro-4-pyridinyl)-N-(3-pyridinyl)benzamide

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: GSK2578215A
Price: ￥6626.0/100mg ￥976.0/10mg ￥1896.0/25mg ￥3506.0/50mg
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: LRRK2 inhibitor GS2578215A
Price: $400.0/100mg $750.0/250mg $1500.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: LRRK2-kinase inhibitor
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Price: $55/10mM*1mLinDMSO

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GSK2578215A

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