DSM265

Modify Date: 2025-08-26 19:39:36

Use of DSM265

DSM265 is a PfDHODH inhibitor with an IC50 of 8.9 nM. DSM265 can also inhibit the growth of P. falciparum 3D7 parasites with an EC50 of 4.3 nM.

Name	DSM265
Synonym	More Synonyms

Description	DSM265 is a PfDHODH inhibitor with an IC50 of 8.9 nM. DSM265 can also inhibit the growth of P. falciparum 3D7 parasites with an EC50 of 4.3 nM.
Related Catalog	Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Infection
Target	IC50: 8.9 nM (PfDHODH)[1] EC50: 4.3 nM (P. falciparum 3D7 parasites)[1]
References	[1]. Kokkonda S, et al. Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparumDihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity. J Med Chem. 2016 Jun 9;59(11):5416-31.

Molecular Formula	C₁₄H₁₂F₇N₅S
Molecular Weight	415.332
Exact Mass	415.070160
LogP	3.76
InChIKey	OIZSVTOIBNSVOS-UHFFFAOYSA-N
SMILES	Cc1cc(Nc2ccc(S(F)(F)(F)(F)F)cc2)n2nc(C(C)(F)F)nc2n1
Storage condition	2-8℃

Sulfur, [4-[[2-(1,1-difluoroethyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-yl]amino]phenyl]pentafluoro-

2-(1,1-Difluoroethyl)-5-methyl-N-[4-(pentafluoro-λ6-sulfanyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine

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Price: $302/10mM*1mLinDMSO

Reference only. check more DSM265 price