DSM265

Names

[ CAS No. ]:
1282041-94-4

[ Name ]:
DSM265

[Synonym ]:
Sulfur, [4-[[2-(1,1-difluoroethyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-yl]amino]phenyl]pentafluoro-
2-(1,1-Difluoroethyl)-5-methyl-N-[4-(pentafluoro-λ6-sulfanyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine

Biological Activity

[Description]:

DSM265 is a PfDHODH inhibitor with an IC50 of 8.9 nM. DSM265 can also inhibit the growth of P. falciparum 3D7 parasites with an EC50 of 4.3 nM.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Parasite

Research Areas >> Infection

[Target]

IC50: 8.9 nM (PfDHODH)[1] EC50: 4.3 nM (P. falciparum 3D7 parasites)[1]

[References]

[1]. Kokkonda S, et al. Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparumDihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity. J Med Chem. 2016 Jun 9;59(11):5416-31.

[Related Small Molecules]

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₁₂F₇N₅S

[ Molecular Weight ]:
415.332

[ Exact Mass ]:
415.070160

[ LogP ]:
3.76

[ Storage condition ]:
2-8℃

Related Compounds

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