(rac)-Etodolac-d3

Modify Date: 2025-09-12 14:30:45

(rac)-Etodolac-d3 structure	Common Name	(rac)-Etodolac-d3
	CAS Number	1276197-46-6	Molecular Weight	290.372
	Density	1.2±0.1 g/cm3	Boiling Point	507.9±45.0 °C at 760 mmHg
	Molecular Formula	C₁₇H₁₈D₃NO₃	Melting Point	N/A
	MSDS	N/A	Flash Point	261.0±28.7 °C

Use of (rac)-Etodolac-d3

(Rac)-Etodolac-d3 ((Rac)-AY-24236-d3) is a labelled racemic Etodolac. Etodolac (AY-24236) is a non-steroidal anti-inflammatory compound that is a non-selective inhibitor of COX (IC50=53.5 nM)

Name	{8-Ethyl-1-[(2,2,2-2H3)ethyl]-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl}acetic acid
Synonym	More Synonyms

Description	(Rac)-Etodolac-d3 ((Rac)-AY-24236-d3) is a labelled racemic Etodolac. Etodolac (AY-24236) is a non-steroidal anti-inflammatory compound that is a non-selective inhibitor of COX (IC50=53.5 nM)
Related Catalog	Research Areas >> Cancer Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17. [3]. Ito S, Tajima K, Nogawa M et al. Etodolac, a cyclooxygenase-2 inhibitor, attenuates paclitaxel-induced peripheral neuropathy in a mouse model of mechanical allodynia. J Pharmacol Exp Ther. 2012 Jul;342(1):53-60. [4]. Yanaoka K, Oka M, Yoshimura N et al. Preventive effects of etodolac, a selective cyclooxygenase-2 inhibitor, on cancer development in extensive metaplastic gastritis, a Helicobacter pylori-negative precancerous lesion. Int J Cancer. 2010 Mar 15;126(6):1467-73. [5]. Matsuyama M, Yoshimura R, Hase T et al. Administration of the selective cyclooxygenase (COX)-2 inhibitor etodolac prolongs cardiac allograft survival in a mouse model. Mol Med Report. 2010 Sep-Oct;3(5):771-4.

Density	1.2±0.1 g/cm3
Boiling Point	507.9±45.0 °C at 760 mmHg
Molecular Formula	C₁₇H₁₈D₃NO₃
Molecular Weight	290.372
Flash Point	261.0±28.7 °C
Exact Mass	290.170959
LogP	3.59
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.597
InChIKey	NNYBQONXHNTVIJ-BMSJAHLVSA-N
SMILES	CCc1cccc2c3c([nH]c12)C(CC)(CC(=O)O)OCC3

{8-Ethyl-1-[(2,2,2-H)ethyl]-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl}acetic acid

Pyrano[3,4-b]indole-1-acetic acid, 8-ethyl-1-(ethyl-2,2,2-d)-1,3,4,9-tetrahydro-

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(rac)-Etodolac-d3

Use of (rac)-Etodolac-d3

Names

(rac)-Etodolac-d3 Biological Activity

Chemical & Physical Properties

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.