(rac)-Indapamide-d3

Modify Date: 2024-01-08 19:28:49

(rac)-Indapamide-d3 Structure
(rac)-Indapamide-d3 structure
Common Name (rac)-Indapamide-d3
CAS Number 1217052-38-4 Molecular Weight 368.853
Density 1.5±0.1 g/cm3 Boiling Point N/A
Molecular Formula C16H13D3ClN3O3S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of (rac)-Indapamide-d3


(Rac)-Indapamide-d3 is a labelled racemic Indapamide. Indapamide is an orally active sulphonamide diuretic agent, that can reduce blood pressure by decreasing vascular reactivity and peripheral vascular resistance. Indapamide is also can reduce left ventricular hypertrophy[1][4].

 Names

Name 4-Chloro-N-[2-(2H3)methyl-2,3-dihydro-1H-indol-1-yl]-3-sulfamoylbenzamide
Synonym More Synonyms

 (rac)-Indapamide-d3 Biological Activity

Description (Rac)-Indapamide-d3 is a labelled racemic Indapamide. Indapamide is an orally active sulphonamide diuretic agent, that can reduce blood pressure by decreasing vascular reactivity and peripheral vascular resistance. Indapamide is also can reduce left ventricular hypertrophy[1][4].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Chaffman, M, et, al. Indapamide. Drugs 28, 189–235 (1984).

[3]. Furman BL, et, al. A further examination of the possible effects of indapamide on glucose tolerance and insulin secretion in the rat and mouse. J Pharm Pharmacol. 1981 Nov;33(11):735-7.

[4]. Lalande A, et, al. Indapamide, a thiazide-like diuretic, decreases bone resorption in vitro. J Bone Miner Res. 2001 Feb;16(2):361-70.

[5]. Ma F, et, al. Indapamide lowers blood pressure by increasing production of epoxyeicosatrienoic acids in the kidney. Mol Pharmacol. 2013 Aug;84(2):286-95.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Molecular Formula C16H13D3ClN3O3S
Molecular Weight 368.853
Exact Mass 368.078918
LogP 2.10
Index of Refraction 1.694

 Synonyms

Benzamide, 3-(aminosulfonyl)-4-chloro-N-[2,3-dihydro-2-(methyl-d3)-1H-indol-1-yl]-
4-Chloro-N-[2-(2H3)methyl-2,3-dihydro-1H-indol-1-yl]-3-sulfamoylbenzamide