colistimethate

Modify Date: 2024-01-06 18:16:12

colistimethate structure	Common Name	colistimethate
	CAS Number	12705-41-8	Molecular Weight	1625.883
	Density	1.5±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₅₇H₁₀₈N₁₆O₂₈S₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of colistimethate

Colistimethate is a polymyxin with cytotoxicity to renal tubular cells. Colistimethate has poorly inactive in vivo. Colistimethate shows seldomly detectable activity against 6 strains of P. aeruginosa[1][2].

Name	{[(3S)-4-{[(3S,6S,9S,12S,15R,18S,21S)-3-[(1R)-1-Hydroxyethyl]-12,15-diisobutyl-2,5,8,11,14,17,20-heptaoxo-6,9,18-tris{2-[(sulfomethyl)amino]ethyl}-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]amino}-3-{[(2S,3R)-3-hydroxy-2-({(2S)-2-[(6-methylheptanoyl)amino]-4-[(sulfomethyl)amino]butanoyl}amino)butanoyl]amino}-4-oxobutyl]amino}methanesulfonic acid
Synonym	More Synonyms

Description	Colistimethate is a polymyxin with cytotoxicity to renal tubular cells. Colistimethate has poorly inactive in vivo. Colistimethate shows seldomly detectable activity against 6 strains of P. aeruginosa[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	Colistimethate 对肾小管细胞有细胞毒性[1]。
In Vivo	Colistimethate 容易在体内引起肾毒性[1]。 Colistimethate (306 mg/kg; 皮下注射; 单次剂量) 在小鼠体内对 P. aeruginosa 菌株 (i.p.) 相对无效[2]。
References	[1]. Zavascki AP, et al. Nephrotoxicity of Polymyxins: Is There Any Difference between Colistimethate and Polymyxin B? Antimicrob Agents Chemother. 2017 Feb 23;61(3):e02319-16. [2]. Davis SD. Activity of gentamicin, tobramycin, polymyxin B, and colistimethate in mouse protection tests with Pseudomonas aeruginosa. Antimicrob Agents Chemother. 1975 Jul;8(1):50-3.

Density	1.5±0.1 g/cm3
Molecular Formula	C₅₇H₁₀₈N₁₆O₂₈S₅
Molecular Weight	1625.883
Exact Mass	1624.612305
LogP	-12.35
Index of Refraction	1.609

{[(3S)-4-{[(3S,6S,9S,12S,15R,18S,21S)-3-[(1R)-1-Hydroxyethyl]-12,15-diisobutyl-2,5,8,11,14,17,20-heptaoxo-6,9,18-tris{2-[(sulfomethyl)amino]ethyl}-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]amino}-3-{[(2S,3R)-3-hydroxy-2-({(2S)-2-[(6-methylheptanoyl)amino]-4-[(sulfomethyl)amino]butanoyl}amino)butanoyl]amino}-4-oxobutyl]amino}methanesulfonic acid

2,6,9,14-Tetraazapentadecane-1,15-disulfonic acid, 8-[(1R)-1-hydroxyethyl]-5-[[[(3S,6S,9S,12S,15R,18S,21S)-3-[(1R)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-6,9,18-tris[2-[(sulfomethyl)amino]ethyl]-1,4,7,10,13,16,19-heptaazacyclotricos-21-yl]amino]carbonyl]-11-[(6-methyl-1-oxoheptyl)amino]-7,10-dioxo-, (5S,8S,11S)-

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: colistimethate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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