(-)-PX20606 trans isomer

Modify Date: 2024-01-10 08:13:55

Use of (-)-PX20606 trans isomer

(-)-PX20606 trans isomer is a FXR agonist with EC50s of 18 and 29 nM for FXR in FRET and M1H assay, respectively.

Name	378SU5NO8S
Synonym	More Synonyms

Description	(-)-PX20606 trans isomer is a FXR agonist with EC50s of 18 and 29 nM for FXR in FRET and M1H assay, respectively.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> FXR Research Areas >> Metabolic Disease
Target	EC50: 18 nM (FXR in FRET assay), 29 nM (FXR in M1H assay)[1]
References	[1]. Kinzel O, et al. Novel substituted isoxazole FXR agonists with cyclopropyl, hydroxycyclobutyl and hydroxyazetidinyl linkers: Understanding and improving key determinants of pharmacological properties. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3746-53.

Molecular Formula	C₂₉H₂₂Cl₃NO₄
Molecular Weight	553.06

6TU6SUZ3BY

UNII:6TU6SUZ3BY

UNII:378SU5NO8S

Benzoic acid, 4-[(1S,2S)-2-[2-chloro-4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl]methoxy]phenyl]cyclopropyl]-

4-[(1S,2S)-2-(2-Chloro-4-{[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy}phenyl)cyclopropyl]benzoic acid

378SU5NO8S

(-)-PX20606 trans isomer

Get all suppliers and price by the below link:

Price: ￥16784/10 mM * 1 mL in DMSO