Etelcalcetide

Modify Date: 2025-08-25 17:07:07

Etelcalcetide Structure
Etelcalcetide structure
Common Name Etelcalcetide
CAS Number 1262780-97-1 Molecular Weight 1048.25000
Density N/A Boiling Point N/A
Molecular Formula C38H73N21O10S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Etelcalcetide


Etelcalcetide (AMG 416) is a synthetic peptide as an activator of the calcium sensing receptor (CaSR). Etelcalcetide is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis[1].

 Names

Name Etelcalcetide
Synonym More Synonyms

 Etelcalcetide Biological Activity

Description Etelcalcetide (AMG 416) is a synthetic peptide as an activator of the calcium sensing receptor (CaSR). Etelcalcetide is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis[1].
Related Catalog
References

[1]. Block GA, et al. Effect of Etelcalcetide vs Cinacalcet on Serum Parathyroid Hormone in Patients Receiving Hemodialysis With Secondary Hyperparathyroidism: A Randomized Clinical Trial. JAMA. 2017 Jan 10;317(2):156-164.

 Chemical & Physical Properties

Molecular Formula C38H73N21O10S2
Molecular Weight 1048.25000
Exact Mass 1047.53000
PSA 608.31000
LogP 1.67200
InChIKey ANIAZGVDEUQPRI-ZJQCGQFWSA-N
SMILES CC(=O)NC(CSSCC(N)C(=O)O)C(=O)NC(C)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(C)C(=O)NC(CCCN=C(N)N)C(N)=O
Storage condition 2-8°C

 Synonyms

Velcalcetide
AMG 416
KAI 4169
ONO 5163
Telcalcetide
Parsabiv
H-Cys(1)-OH.Ac-D-Cys(1)-D-Ala-D-Arg-D-Arg-D-Arg-D-Ala-D-Arg-NH2
N-acetyl-D-cysteinyl-D-alanyl-D-arginyl-D-arginyl-D-arginyl-D-alanyl-D-argininamide disulfide with L-cysteine
N-acetyl-D-cysteinyl-S-(L-cysteine disulfide)-D-alanyl-D-arginyl-D-arginyl-D-arginyl-D-alanyl-D-argininamide
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