Etelcalcetide

Names

[ Name ]:
Etelcalcetide

[Synonym ]:
Velcalcetide
AMG 416
KAI 4169
ONO 5163
Telcalcetide
Parsabiv
H-Cys(1)-OH.Ac-D-Cys(1)-D-Ala-D-Arg-D-Arg-D-Arg-D-Ala-D-Arg-NH2
N-acetyl-D-cysteinyl-D-alanyl-D-arginyl-D-arginyl-D-arginyl-D-alanyl-D-argininamide disulfide with L-cysteine
N-acetyl-D-cysteinyl-S-(L-cysteine disulfide)-D-alanyl-D-arginyl-D-arginyl-D-arginyl-D-alanyl-D-argininamide

Biological Activity

[Description]:

Etelcalcetide (AMG 416) is a synthetic peptide as an activator of the calcium sensing receptor (CaSR). Etelcalcetide is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis[1].

[Related Catalog]:

Research Areas >> Endocrinology

Signaling Pathways >> GPCR/G Protein >> CaSR

[References]

[1]. Block GA, et al. Effect of Etelcalcetide vs Cinacalcet on Serum Parathyroid Hormone in Patients Receiving Hemodialysis With Secondary Hyperparathyroidism: A Randomized Clinical Trial. JAMA. 2017 Jan 10;317(2):156-164.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₈H₇₃N₂₁O₁₀S₂

[ Molecular Weight ]:
1048.25000

[ Exact Mass ]:
1047.53000

[ PSA ]:
608.31000

[ LogP ]:
1.67200

[ Storage condition ]:
2-8°C

Related Compounds

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